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Non-lymphomatous Brain Tumors in HIV-1 Infection: A Review

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Abstract

A broad spectrum of malignant tumors affecting various organ systems in HIV-1 infected patients have been described in larger series. Intracerebral mass lesions encountered in HIV-1 infection are mostly due to toxoplasmosis and central nervous system (CNS) lymphoma. Brain tumors (excluding lymphomas) occurring in HIV-1 infected patients have only occasionally been described. The present review summarizes these diverse tumor entities and reports on the controversial theories of a possible oncogenic potential of HIV-1. Although rare, intracerebral tumors must be considered in the differential diagnosis of an intracranial space-occupying lesion in an HIV-1 infected patient.

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References

  1. Budka H, Wiley CA, Kleihues P, Artigas J, Asbury AK, Cho E-K, Cornblath DR, Dal Canto MC, DeGirolami U, Dickson DW, Epstein LG, Esiri MM, Giangaspero F, Gosztonyi G, Gray F, Griffin JW, Hénin D, Iwasaki Y, Janssen RS, Johnson RT, Lantos PL, Lyman WD, McArthur JC, Nagashima K, Peress N, Petito CK, Price RW, Rhodes RH, Rosenblum M, Said G, Scaravilli F, Sharer LR, Vinters HV: HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology. Brain Pathology 1: 143–152, 1991

    Google Scholar 

  2. Weis S, Bise K, Llenos IC, Mehraein P: Neuropathologic features of the brain in HIV-1 infection. In:Weis S, Hippius H (eds) HIV-1 Infection of the Central Nervous System. Clinical, Pathological, and Molecular Aspects. Hogrefe & Huber Publishers, Seattle, 1992, pp 159–190

    Google Scholar 

  3. DeAngelis LM: Primary brain tumors in the acquired immunodeficiency syndrome. Curr Opin Neurol 8: 419–423, 1995

    PubMed  Google Scholar 

  4. Gildenberg PL, Langford L, Kim JH, Trujillo R: Stereotactic biopsy in cerebral lesions of AIDS. Acta Neurochir 59(suppl): 68–70, 1993

    Google Scholar 

  5. Levy RM, Pons VG, Rosenblum ML: Central nervous system mass lesions in the acquired immunodeficiency syndrome (AIDS). J Neurosurg 61: 9–16, 1984

    Google Scholar 

  6. Matthiessen L, Marche C, Labrousse F, Trophilme D, Fontaine C, Vedrenne C: Étude neuropathologique de l'encéphale de 174 patients morts du SIDA dans un hopital parisien, de 1982 à 1988. Ann Med Interne Paris 143: 43–49, 1992

    Google Scholar 

  7. Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumours of the Central Nervous System. Springer-Verlag, Berlin, 1993

    Google Scholar 

  8. Burger PC, ScheithauerBW: Tumors of the Central Nervous System. Third Series. Armed Forces Institute of Pathology, Washington, D.C. 1994

    Google Scholar 

  9. Weill O, Finaud M, Bille F, Gastaut JL, Gastaut JA, Malca S, Vincentelli F: Gliome malin medullaire. Une nouvelle complication de 1'infection par le virus HIV? [letter]. Presse Med 16: 1977, 1987

    Google Scholar 

  10. Gasnault J, Roux FX, Vedrenne C: Cerebral astrocytoma in association with HIV infection. J Neurol Neurosurg Psychiat 51: 422–424, 1988

    Google Scholar 

  11. Carrana EJ, Rossitch E, Moore MR, Funkenstein HH: Anaplastic astrocytoma in association with human immunodeficiency virus type 1 infection [letter]. Am J Emerg Med 8: 565–567, 1990

    Article  Google Scholar 

  12. Ho K-L, Gottlieb C, Zarbo RJ: Cytomegalovirus infection of cerebral astrocytoma in an AIDS patient. Clin Neuropathol 10: 127–133, 1991

    PubMed  Google Scholar 

  13. Chappell ET, Guthrie ML, Orenstein J: The role of stereotactic biopsy in the management of HIV-related focal brain lesions. Neurosurgery 30: 825–829, 1992

    PubMed  Google Scholar 

  14. Hajjar M, Lacoste D, Brossard G, Dupon M, Salmi LR, Dabis F: Non-acquired immune deficiency syndromedefining malignancies in a hospital-based cohort of human immunodeficiency virus-infected patients: Bordeaux, France, 1985–1991. J Natl Cancer Inst 84: 1593–1595, 1992

    PubMed  Google Scholar 

  15. Kasantikul V, Kaoroptham S, Hanvanich M: Acquired immunodeficiency syndrome associated with cerebral astrocytoma. Clin Neuropathol 11: 25–27, 1992

    PubMed  Google Scholar 

  16. Petty RKH, Kennedy PGE: The neurological features of HIV-positive patients in Glasgow – a retrospective study of 90 cases. Quart J Med 299: 223–234, 1992

    Google Scholar 

  17. Crosato IM, Tirelli U, Vaccher E, Clerici M, De Lalla F, Faustini M, Gritti F, Lazzarin A, Magnani G, Marini B, Piersantelli N, Pizzocaro G, Rizzi M, Rosso R, Sinicco A, Sueri L, Torresin A, Monfardini S: Tumori solidi in associazione all'infezione da HIV. Minerva Med 84: 89–94, 1993

    PubMed  Google Scholar 

  18. Mikol J: Other Types of Tumours. In: Gray F (ed) Atlas of the Neuropathology of HIV Infection. Oxford University Press, Oxford, 1993, pp 146–147

    Google Scholar 

  19. Chamberlain MC: Gliomas in patients with acquired immune deficiency syndrome. Cancer 74: 1912–1914, 1994

    PubMed  Google Scholar 

  20. Mandel M, Toren A, Hadani M, Engelberg I, Martinowitz U, Rechavi G: Ependymoblastoma in an HIV-positive hemophilic girl. Med Pediatr Oncol 23: 441–443, 1994

    PubMed  Google Scholar 

  21. Moulignier A, Mikol I, Pialoux G, Eliaszewicz M, Thurel C, Thiébaut JB: Cerebral glial tumors and human immunode-ficiency virus-1 infection. More than a coincidental association. Cancer 74: 686–692, 1994

    PubMed  Google Scholar 

  22. Gervasoni C, Ridolfo AL, Rocca A, Vago L, d'Arminio-Monforte A: Cerebral astrocytoma in HIV-infected patients [letter]. AIDS 9: 403–404, 1995

    PubMed  Google Scholar 

  23. Steinmetz H, Arendt E, Hefter H, Neuen-Jacob E, Dörries K, Aulich A, Kahn T: Focal brain lesions in patients with AIDS: aetiologies and corresponding radiological patterns in a prospective study. J Neurol 242: 69–74, 1995

    PubMed  Google Scholar 

  24. Büttner A, Itoh K, Mehraein P, Weis S: CMV-infected subependymoma in the fourth ventricle of an HIV-1 infected patient. J Neurovirol 2: 191–194, 1996

    PubMed  Google Scholar 

  25. Neal JW, Llewelyn MB, Morrison HL, Jasani B, Borysiewicz LK: A malignant astrocytoma in a patient with AIDS: a possible association between astrocytomas andHIV infection. J Infect 33: 159–162, 1996

    Article  PubMed  Google Scholar 

  26. Tacconi L, Stapleton S, Signorelli F, Thomas DG: Acquired immune deficiency syndrome (AIDS) and cerebral astrocytoma. Clin Neurol Neurosurg 98: 149–151, 1996

    Article  PubMed  Google Scholar 

  27. d'Arminio-Monforte A, Cinque P, Vago L, Rocca A, Gervasoni C, Terreni MR, Novati R, Gori A, Lazzarin A, Moroni M: A comparison of brain biopsy and CSF-PCR in the diagnosis of CNS lesions in AIDS patients. J Neurol 244: 35–39, 1997

    PubMed  Google Scholar 

  28. Majtényi C: Primary brain tumours in AIDS patients ['Abstract']. Brain Pathol 7: 1209, 1997

    Google Scholar 

  29. Waubant E, Delisle MB, Bonafé A, Gray F, Clanet M: Cervical cord glioma in an HIV positive patient. Eur Neurol 39: 58–60, 1998

    PubMed  Google Scholar 

  30. BeralV, Jaffe H, Weiss R: Overview: cancer, HIV and AIDS. Cancer Surv 10: 1–3, 1991

    Google Scholar 

  31. Tirelli U, Errante D, Carbone A, Gloghini A, Vaccher E: Malignant tumors in patients with HIV infection. Crit Rev Oncol Hematol 24: 165–184, 1996

    PubMed  Google Scholar 

  32. Büttner A, Marquart KH, Mehraein P, Weis S: Kaposi's sarcoma in the cerebellum of a patient with AIDS. Clin Neuropathol 16: 185–189, 1997

    PubMed  Google Scholar 

  33. Monfardini S, Vaccher E, Pizzocaro G, Stellini R, Sinicco A, Sabbatani S, Marangolo M, Zagni R, Clerici M, Fo`a R, Tirelli U, Gavosto F: Unusual malignant tumours in 49 patients with HIV infection. AIDS 3: 449–452, 1989

    PubMed  Google Scholar 

  34. Serraino D, Franceschi S, Tirelli U, Monfardini S: The epidemiology of acquired immunodeficiency syndrome and associated tumours in Europe. Ann Oncol 3: 595–603, 1992

    PubMed  Google Scholar 

  35. Goedert JJ, Coté TR, Virgo P, Scoppa SM, Kingma DW, GailMH, Jaffe ES, Biggar RJ: Spectrum of AIDS-associated malignant disorders. Lancet 351: 1833–1839, 1998

    Article  PubMed  Google Scholar 

  36. Rabkin CS, Yellin F: Cancer incidence in a population with a high prevalence of infection with human immunodeficiency virus type 1. J Natl Cancer Inst 86: 1711–1716, 1994

    PubMed  Google Scholar 

  37. Bigner DD, Pegram CN: Virus-induced experimental brain tumors and putative associations of viruses with human brain tumors; a review. Adv Neurol 15: 57–83, 1976

    PubMed  Google Scholar 

  38. Luppi M, Barozzi P, Maiorana A, Maiorana A, Marasca R, Trovato R, Fano R, Ceccherini-Nelli L, Torelli G: Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. J Med Virol 47: 105–111, 1995

    PubMed  Google Scholar 

  39. Walker JS, Bigner DD: Virus-Induced Brain Tumors. In: Wilkins RH, Rengachary 55 (eds) Neurosurgery. McGraw-Hill Book Company, New York, 1985, pp 522–525

    Google Scholar 

  40. Walsh JW, Zimmer SG, Perdue ML: Role of viruses in the induction of primary intracranial tumors. Neurosurgery 10: 643–662, 1982

    PubMed  Google Scholar 

  41. ZuRhein GM: The role of human viruses in neurooncogenesis. J Neuropathol Exp Neurol Suppl.: 50S–52S, 1995

  42. Ibelgaufts H, JonesKW, Maitland N, Shaw JF: Adenovirusrelated RNA sequences in human neurogenic tumours. Acta Neuropathol 56: 113–117, 1982

    Article  PubMed  Google Scholar 

  43. Ibelgaufts H, Jones KW: Papovavirus-related RNA sequences in human neurogenic tumours. Acta Neuropathol 56: 118–122, 1982

    Article  PubMed  Google Scholar 

  44. Benjamin SP, McCormack U, Dohn DF: Coexistent herpes simplex encephalitis and malignant astrocytoma. A clinicopathologic study of three cases. Cleveland Clin Quart 39: 135–143, 1972

    PubMed  Google Scholar 

  45. Conant K, Tornatore C, Atwood W, Meyers K, Traub R, Major EO: In vivo and in vitro infection of the astrocyte by HIV-1. Adv Neuroimmunol 4: 287–289, 1994

    PubMed  Google Scholar 

  46. Nath A, Hartloper V, Furer M, Fowke KR: Infection of human fetal astrocytes with HIV-1: viral tropism and the role of cell to cell contact in viral transmission. J Neuropathol Exp Neurol 54: 320–330, 1995

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Legal Medicine, Ludwig-Maximilians-University, Munich, Germany

    Andreas Büttner

  2. Institute of Neuropathology, Ludwig-Maximilians-University, Munich, Germany

    Serge Weis

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  1. Andreas Büttner
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  2. Serge Weis
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Büttner, A., Weis, S. Non-lymphomatous Brain Tumors in HIV-1 Infection: A Review. J Neurooncol 41, 81–88 (1999). https://doi.org/10.1023/A:1006137219766

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