Abstract
Determining the primary site of a cerebral metastatic adenocarcinoma is complicated by the histologic similarity of most adenocarcinomas. Thyroid Transcription Factor-1 (TTF-1) is a highly specific marker of peripheral airway cell neoplasms. Formalin fixed tissue from 30 patients with brain metastasis whose primary sources were clinically and histologically known with certainty were analyzed for immunoreactivity to TTF-1. There were 18 cases of metastatic lung adenocarcinoma. Other metastases were from breast (6), colon (1), prostate (1), kidney (1), paranasal sinus (1), melanoma (1), and intestinal carcinoid (1). No patients with carcinoma of the thyroid were found. Positivity was regarded as intense nuclear reactivity. Twelve (67%) metastatic lung adenocarcinomas stained for TTF- 1. None of the cerebral metastases from other body sites showed positivity. In addition, normal brain tissue and astrocytic tumors did not stain for TTF-1. These data show that TTF-1 is a highly specific and reasonably sensitive marker for peripheral airway cell metastasis to the brain.
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Nussbaum ES, Djalilian HR, Cho KH, Hall WA: Brain metastasis. Histology, multiplicity, surgery, and survival. Cancer 78: 1781–1788, 1996
Debevec M: Management of patients with brain metastases of unknown origin. Neoplasma 37: 601–606, 1990
Delattre JY, Krol G, Thaler HT, Posner JB: Distribution of brain metastases. Arch Neurol 45: 741–744, 1988
le Chevalier T, Smith FP, Caille P, Constans JP, Rouesse JG: Sites of primary malignancies in patients presenting with cerebral metastases: a review of 120 cases. Cancer 56: 880–882, 1985
Eapen L, Vachet M, Catton G, Danjoux C, McDermot R, Nair B, Girard A, Genest P, Stewart D, Gerig L: Brain metastases with an unknown primary tumor: a clinical perspective. J Neuroncol 6: 31–35, 1988
Salvati M, Cervoni L, Raco A: Single brain metastases from unknown primary malignancies in the CT-era. J Neuro-One 23: 75–80, 1995
Merchut MP: Brain metastases from undiagnosed systemic neoplasms. Arch Intern Med 149: 1076–1080, 1989
van de Pol M, van Aalst VC, Wilmink JT, Twijnstra A: Brain metastases from unknown primary tumour: which diagnostic procedures are indicated? J Neurol Neurosurg Psychiatry 61: 321–323, 1996
Raab SS, Berg LC, Swanson PE, Wick MR: Adenocarcinoma in the lung in patients with breast cancer: a prospective analysis of the discriminatory value of immunohistology. Am J Clin Pathol 100: 27–35, 1993
Lazzaroo D, Price M, De Felice M, Di Lauro R: The transcription factor TTF-1 is expressed at the onset of throid and lung morphogenesis and in restricted regions of the foetal brain. Development 113: 1093–1104, 1991
Bohinski RJ, Di Lauro R, Whitsett JA: The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor-1 and hepatocyte nuclear factor-3, indicating common factors for organ-specific gene expression along the foregut axis. Mol Cell Biol 14: 5671–5681, 1994
Holzinger A, Dingle S, Bejarano PA, Miller MA, Weaver TE, Di Lauro R, Whitsett JA: Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis. Hybridoma 15: 49–53, 1996
Bejarano PA, Baughman RP, Biddinger PW, Miller MA, Fenoglio-Preiser C, Al-Kafaji B, Di Lauro R, Whitsett JA: Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas. Mod Pathol 9: 445–452, 1996
Leong AS-Y, Wright J: The contribution of immunohistochemical staining in tumour diagnosis. Histopathology 11: 1295–1305, 1987
Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM: Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas. Appl Immunohistochem 3: 99–107, 1995
Perry A, Parisi JE, Kurtin PJ: Metastatic adenocarcinoma to the brain: an immunohistochemical approach. Hum Pathol 28: 938–943, 1997
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Bohinski, R., Bejarano, P., Balko, G. et al. Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1. J Neurooncol 40, 227–231 (1998). https://doi.org/10.1023/A:1006102607697
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DOI: https://doi.org/10.1023/A:1006102607697