Veterinary Research Communications

, Volume 22, Issue 4, pp 249–255 | Cite as

Novel p53 tumour suppressor mutations in cases of spindle cell sarcoma, pleomorphic sarcoma and fibrosarcoma in cats

  • B. Mayr
  • M. Reifinger
  • K. Alton
  • G. Schaffner

Abstract

Twenty feline neoplasms were sequenced in the region from exons 5 to 8 for the presence of tumour suppressor gene p53 mutations. In a spindle cell sarcoma of the bladder, a missense mutation (codon 164 AAG→GAG, lysine→glutamic acid) in exon 5 was detected. In a pleomorphic sarcoma, a 23 bp deletion involving the splicing junction between intron 5 and exon 6 was observed. In a fibrosarcoma, a 6 bp deletion of p53 covering 2 bp of exon 7 and 4 bp of intron 7, including the splicing junction, was found. The study demonstrates three new p53 mutations in different types of sarcomas in cats.

cat mutation p53 gene sarcoma tumour 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • B. Mayr
    • 1
  • M. Reifinger
    • 2
  • K. Alton
    • 2
  • G. Schaffner
    • 3
  1. 1.Institute for Animal Breeding and Genetics, Veterinary UniversityViennaAustria
  2. 2.Institute for Pathology and Forensic Veterinary Medicine, Veterinary UniversityViennaAustria
  3. 3.Research Institute of Molecular Pathology, Dr Bohr-Gasse 7ViennaAustria

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