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RETRACTED ARTICLE: Cerebrospinal fluid ferritin in glioblastoma: Evidence for tumor synthesis

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This article was retracted on 29 July 2019

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Abstract

Ferritin concentrations in cerebrospinal fluid (CSF) of 16 patients with glioblastoma were found to be very high (mean, 103.0 ng/mL) relative to 29 patients with viral meningitis and 20 patients with headache (mean concentrations, 5.4 and 4.3 ng/mL respectively). Simultaneous measurement of ferritin in CSF and serum revealed CSF concentrations exceeding those in serum in 11 of 16 patients with glioblastoma (CSF vs. serum ratio, 132.6%), contrasting with very low ratios in patients with meningitis (7.9%) or headache (4.9%). Ferritin was detected immunocytochemically in tumor cell cytoplasm in a resected glioblastoma. Thus, ferritin in CSF appears to be produced by glioblastoma cells, with a biologic significance requiring further investigation.

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Change history

  • 29 July 2019

    The Editor-in-Chief has retracted this article [1]. An investigation by Kurume University has not been able to establish what the appropriate authorship should be because one of the authors, Yoshihiro Sato, is now deceased. As the appropriate authorship cannot be determined the Editor-in-Chief no longer has confidence in this article. Kurume University has also stated that it has not been possible to verify the data presented as none of the research material is available for investigation. We have not been able to contact Yoshiaki Honda, Takeshi Asoh, Kotaro Oizumi, Yuki Ohshima and Eiichiro Honda about this retraction.

  • 29 July 2019

    The Editor-in-Chief has retracted this article [1]. An investigation by Kurume University has not been able to establish what the appropriate authorship should be because one of the authors, Yoshihiro Sato, is now deceased. As the appropriate authorship cannot be determined the Editor-in-Chief no longer has confidence in this article. Kurume University has also stated that it has not been possible to verify the data presented as none of the research material is available for investigation. We have not been able to contact Yoshiaki Honda, Takeshi Asoh, Kotaro Oizumi, Yuki Ohshima and Eiichiro Honda about this retraction.

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Authors and Affiliations

  1. Department of Neurology, Futase Social Insurance Hospital, Iizuka

    Yoshihiro Sato, Yoshiaki Honda & Takeshi Asoh

  2. Department of Internal Medicine, Kurume University School of Medicine, Kurume

    Kotaro Oizumi

  3. Department of Neurosurgery, Ohshima Hospital, Kitashigeyasu, Japan

    Yuki Ohshima & Eiichiro Honda

Authors
  1. Yoshihiro Sato
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  2. Yoshiaki Honda
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  3. Takeshi Asoh
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  4. Kotaro Oizumi
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  5. Yuki Ohshima
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  6. Eiichiro Honda
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Additional information

The editor-in-Chief has retracted this article [1]. An investigation by Kurume University has not been able to establish what the appropriate authorship should be because one of the authors, Yoshihiro Sato, is now deceased. As the appropriate authorship cannot be determined the Editor-in-Chief no longer has confidence in this article. Kurume University has also stated that it has not been possible to verify the data presented as none of the research material is available for investigation. We have not been able to contact Yoshiaki Honda, Takeshi Asoh, Kotaro Oizumi, Yuki Ohshima and Eiichiro Honda about this retraction.

1. Sato, Y., Honda, Y., Asoh, T., Oizumi, K., Ohshima, Y., Honda, E. Cerebrospinal fluid ferritin in glioblastoma: Evidence for tumor synthesis. J Neurooncol (1998) 40: 47-50. https://doi.org/10.1023/A:1006078521790

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Sato, Y., Honda, Y., Asoh, T. et al. RETRACTED ARTICLE: Cerebrospinal fluid ferritin in glioblastoma: Evidence for tumor synthesis. J Neurooncol 40, 47–50 (1998). https://doi.org/10.1023/A:1006078521790

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  • DOI: https://doi.org/10.1023/A:1006078521790

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