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Pre-operative assessment of axillary lymph node status in patients with breast adenocarcinoma using intravenous 99mtechnetium mAb-170H.82 (Tru-Scint®AD™)

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Abstract

Immunoscintigraphy of the axilla has potential utility for the diagnosticand prognostic assessment of patients with breast adenocarcinoma.mAb-170H.82 is a murine monoclonal antibody (mAb) derived against syntheticThomsen-Friedenreich (TF) antigen. Tru-Scint®AD™, a99mTc-mAb-170H.82 immunoconjugate, has previously been shownto localize in various human adenocarcinomas. The purpose of this study wasto evaluate the accuracy of this immunoconjugate in the pre-operativeassessment of axillary lymph nodes in patients with known breastadenocarcinoma. Sixteen patients with documented primary breast cancer wereinjected intravenously with 1 mg of immunoconjugate (radioactivity 1.8 GBq)and imaged 22–24 hrs post-injection. Both planar and single photonemission computed tomographic (SPECT) images were obtained and reviewed in ablinded fashion. Imaging results were compared with surgical andpathological findings. Seven of 16 patients were found to havehistologically positive axillary nodes: 5 of these sites were detected byimmunoscintigraphy (sensitivity = 71%). Nine patients hadpathologically disease-free axillary nodes: only 1 of these wasmisidentified as positive by immunoscintigraphy(specificity = 89%). These results suggest thatimmunoscintigraphy with 99mTc-mAb-170H.82 has promise in thedetection of axillary lymph node involvement in patients with breast cancer.Further studies are warranted to define the role of immunoscintigraphy inaxillary staging.

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Authors and Affiliations

  1. Department of Surgery, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada

    Sophie Dessureault, Irv Koven, Jean Couture, Beverly Schmocker, Saul Sidlofsky, Hartley Stern & Steven Gallinger

  2. Department of Radiology, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada

    Manzur Damani, Joel Kirsh & Masanori Ichise

  3. Division of Nuclear Medicine, Toronto Hospital, University of Toronto, Toronto, Ontario, M5G 1X5, Canada

    Raymond M. Reilly

  4. Cross Cancer Institute, Edmonton, Alberta, T6N 1H1, Canada

    Alexander J.B. McEwan

  5. Biomira Incorporated, Edmonton, Alberta, T6N 1H1, Canada

    Alexander J.B. McEwan & Graeme Boniface

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  1. Sophie Dessureault
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  2. Irv Koven
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  6. Manzur Damani
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  7. Joel Kirsh
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  10. Alexander J.B. McEwan
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  13. Steven Gallinger
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Dessureault, S., Koven, I., Reilly, R.M. et al. Pre-operative assessment of axillary lymph node status in patients with breast adenocarcinoma using intravenous 99mtechnetium mAb-170H.82 (Tru-Scint®AD™). Breast Cancer Res Treat 45, 29–37 (1997). https://doi.org/10.1023/A:1005878113826

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  • DOI: https://doi.org/10.1023/A:1005878113826

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