Abstract
This study reports on factors predicting response tosecond-line endocrine therapy in 250 patients with breastcancer for which they were assessable for responseby the International Union Against Cancer (UICC) criteria.Clinical details relating to first-line endocrine therapy wereavailable for all patients. We have not includedin this study patients who received first-line endocrinetherapy but did not or have not yetproceeded to second-line hormone therapy – e.g. diedfrom rapidly progressive disease, started chemotherapy for rapidlyprogressive disease, or remained in long-term remission onfirst-line endocrine therapy.One hundred and fifty nine patients (72%) achievedremission (objective response and static disease [OR +SD]) on first-line endocrine therapy with a medianduration of 19 months. For second-line endocrine therapythe remission rate was 53% (132/225) with amedian duration of 15 months. Tumour grade andoestrogen receptor status of the primary tumour wereshown to be independent predictors of response tosecond-line endocrine therapy while response to first-line endocrinetherapy was a predictor of the duration ofresponse to second-line endocrine therapy. In the sub-groupof patients who showed OR or SD toboth first and second-line therapies, there was nocorrelation between the time to progression (TTP) onfirst and second-line therapies.
Similar content being viewed by others
References
Nicholson RI, Bouzubar N, Walker KJ, McClelland R, Dixon AR, Robertson JFR, Ellis IO, Blamey RW: Hormone sensitivity in breast cancer: Influence of heterogeneity of oestrogen receptor expression and cell proliferation. Eur J Cancer 27: 908–913, 1991
Nicholson RI, McClelland RA, Finlay P, Eaton CL, Gullick WJ, Dixon AR, Robertson JFR, Ellis IO, Blamey RW: Relationship between EGF-R, cerbB2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Eur J Cancer 29A: 1018–1023, 1993
Nicholson RI, McClelland RA, Gee JMW, Manning DL, Cannon P, Robertson JFR, Ellis IO, Blamey RW: Transforming growth factor-α and endocrine sensitivity in breast cancer. Cancer Res 54: 1684–1689, 1994
Gee JMW, Ellis IO, Robertson JFR, Willsher P, McClelland RA, Hewitt KN, Blamey RW, Nicholson RI: Immunocytochemical localization of Fos protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int J Cancer 64: 269–273, 1995
Nicholson RI, McClelland RA, Gee JMW, Manning DL, Cannon P, Robertson JFR, Ellis IO, Blamey RW: Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy. Breast Cancer Res Treat 29: 117–125, 1994
Archer SG, Eliopoulos A, Spandidos D, Barnes D, Ellis IO, Blamey RW, Nicholson RI, Robertson JFR: Expression of ras p21 and c-erbB2 in advanced breast cancer and response to first line hormonal therapy. Br J Cancer 72: 1259–1266, 1995
Hayward JL, Carbone PP, Heuson JC, Kumaoka S, Segaloff A, Rubens RD: Assessment of response to therapy in advanced breast cancer. Cancer 39: 1289–1293, 1977
Elston CW, Ellis IO: Prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long term follow up. Histopath 19: 403–410, 1991
Nicholson RI, Campbell FC, Blamey RW, Elston CW, George D, Griffiths K: Steroid receptors in early breast cancer: value in prognosis. J Ster Biochem 15: 193, 1981
Robertson JFR, Bates K, Pearson D, Blamey RW, Nicholson RI: Comparison of two oestrogen receptor assays in the prediction of the clinical course of patients with advanced breast cancer. Br J Cancer 65: 727–730, 1992
Goulding H, Pinder SE, Cannon P, Pearson D, Nicholson RI, Snead D, Bell J, Elston CW, Robertson JFR, Blamey RW, Ellis IO: A new immunohistochemical antibody for the assessment of oestrogen receptor status on routine formalin-fixed tissue samples. Hum Pathol 26: 291–294, 1995
Nicholson RI, Colin P, Francis AB et al.: Evaluation of an enzyme immunoassay for oestrogen receptors in human breast cancer. Cancer Res (Suppl) 46: 4229s–4230s, 1986
Walker KJ, Bouzabar N, Robertson JFR et al.: Immunocytochemical localisation of estrogen receptor in human breast tissue. Cancer Res 48: 6517–6522, 1988
British Breast Group: Assessment of response to treatment in advanced breast cancer. Lancet 2: 38–39, 1974
Robertson JFR, Williams MR, Todd J, Nicholson RI, Morgan DAL, Blamey RW: Factors predicting the response of patients with advanced breast cancer to endocrine (megace) therapy. Eur J Cancer Clin Oncol 25: 469–475, 1989
Howell A, Mackintosh J, Jones M, Redford J, Wagstaff J, Sellwood RA: The definition of the 'no change' category in patients treated with endocrine therapy and chemotherapy for advanced carcinoma of the breast. Eur J Cancer Clin Oncol 24: 1567–1572, 1988
Robertson JFR, Willsher PC, Cheung KL, Blamey RW: The clinical relevance of static disease (no change) category for 6 months on endocrine therapy in patients with breast cancer. Proc ASCO 15: 101, 1996
Williams MR, Todd JH, Ellis IO, Dowle CS, Haybittle JL, Elston CW, Nicholson RI, Griffiths K, Blamey RW: Oestrogen receptor in primary and advanced breast cancer: An 8 year review of 704 cases. Br J Cancer 5: 67–73, 1987
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cheung, K., Willsher, P., Pinder, S. et al. Predictors of response to second-line endocrine therapy for breast cancer. Breast Cancer Res Treat 45, 219–224 (1997). https://doi.org/10.1023/A:1005828731462
Issue Date:
DOI: https://doi.org/10.1023/A:1005828731462