Skip to main content
SpringerLink
Log in

A phase II Southwest Oncology Group study of cisplatin and continuous infusion vinblastine in the treatment of advanced soft tissue sarcoma

  • Published:
Investigational New Drugs Aims and scope Submit manuscript

Abstract

Purpose and Methods: Bone and soft tissue sarcomas currently comprise 1% of adult malignancies and 15% of pediatric malignancies [1]. While doxorubicin and ifosfamide are active agents, no significant impact on survival has been observed. More active regimes are required in sarcoma. This trial studied cisplatin and a 5 day continuous infusion of vinblastine for patients who had had disease progression of advanced soft tissue sarcoma after a doxorubicin based regimen.

Results: Between July 1983 and October 1986, 20 patients entered the study. There were no treatment related deaths. Seven patients required dose adjustment for neutropenia. No responses were observed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1996. CA A Cancer Journal for Clinicians 46: 5–27, 1996.

    Google Scholar 

  2. Yang JC, Rosenberg SA. Glatstein E, Antman K. Sarcomas of soft tissue. In: De Vita VT HSRS, ed. Cancer Principals & Practice of Oncology, 3rd ed. Philadelphia. J.B. Lippincott: 1436–1488, 1993.

    Google Scholar 

  3. Karakousis CP, Holterman OA, Holyoke E. Cisdichlorodiamineplatinum (II) in metastatic soft tissue sarcomas. Cancer Treat Rep 63: 2071–2075, 1979.

    Google Scholar 

  4. Yap HY, Blumenschein GR, Keeting M, Hortobagyi GN, Tashima CK, Loo TL. Vinblastine given as continuous 5 day infusion in the treatment of refractory advanced breast cancer. Cancer Treat Rep 64: 279, 1980.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Columbia University, NY

    Mary Lou Keohan & Karen Antman

  2. Johns Hopkins University, Baltimore, MD

    Michael R. Grever

  3. Ohio State University Health Center, Columbus, OH, USA

    Stanley P. Balcerzak

Authors
  1. Mary Lou Keohan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael R. Grever
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stanley P. Balcerzak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Karen Antman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Keohan, M.L., Grever, M.R., Balcerzak, S.P. et al. A phase II Southwest Oncology Group study of cisplatin and continuous infusion vinblastine in the treatment of advanced soft tissue sarcoma. Invest New Drugs 15, 255–256 (1997). https://doi.org/10.1023/A:1005803921371

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1005803921371

Search

Navigation