Abstract
Intorre, L., Mengozzi, G., Bertini, S., Bagliacca, M., Luchetti, E. and Soldani, G., 1997. The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the Muscovy duck. Veterinary Research Communications, 21 (2), 127-136
The disposition and tissue distribution of enrofloxacin and of its main metabolite ciprofloxacin were investigated in ducks after oral or intramuscular administration of a single dose of 10 mg/kg enrofloxacin. Plasma and tissue concentrations were determined by a HPLC method. The peak concentrations of enrofloxacin after intramuscular administration (1.67 µg/ml at 0.9 h) were higher than after an oral dose (0.99 µg/ml at 1.38 h). The relative bioavailability of enrofloxacin after administration directly into the crop was 68%, while the metabolic conversion of enrofloxacin to ciprofloxacin was quite low (<10%) with both routes of administration. High tissue concentrations and high tissue:plasma concentration ratios were demonstrated for enrofloxacin and ciprofloxacin 24 h after treatment. It was concluded that a dose of 10 mg/kg per day provides serum and tissue concentrations sufficiently high to be effective in the control of many infectious diseases of ducks.
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REFERENCES
Altreuther, P., 1987. Data on chemistry and toxicology of Baytril. Veterinary Medicine Review, 2, 87–89
Anadon, A., Martinez-Larranaga, M.R., Diaz, M.J., Bringas, P., Martinez, M.A., Fernandez-Cruz, M.L., Fernandez, M.C., Fernandez, R., 1995. Pharmacokinetics and residues of enrofloxacin in chickens. American Journal of Veterinary Research, 56, 501–506
Baggot, J.D., 1992. Clinical pharmacokinetics in veterinary medicine. Clinical Pharmacokinetics, 22, 254–273
Baggot, J.D., 1994. Principles of pharmacokinetics and their use in domestic animals. In: Proceedings of the Post-Congress Workshop of the Sixth International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, (Blackwell Scientific, Oxford), 1–47
Bauditz, R., 1990. Enrofloxacin — Clinical evaluation in several animal species. In: F. Simon, P. Lees and G. Semjén (eds), Veterinary Pharmacology, Toxicology and Therapy in Food Producing Animals, (University of Veterinary Science, Unipharma Co. Ltd, Budapest), 21–26
Bergan, T., Dalhoff, A. and Rohwedder, R., 1988. Pharmacokinetics of ciprofloxacin. Infection, 16(Supplement 1), 3–13
Brown, S.A., 1996. Fluoroquinolones in animal health. Journal of Veterinary Pharmacology and Therapeutics, 19, 1–14
Cabanes, A., Arboix, M., Anton, J.M.G. and Reig, F., 1992. Pharmacokinetics of enrofloxacin after intravenous and intramuscular injection in rabbits. American Journal of Veterinary Research, 53, 2090–2093
Chu, D.T.W. and Fernandes, P.B., 1989. Structure-activity relationships of the fluoroquinolones. Antimicrobial Agents and Chemotherapy, 33, 131–135
Dorrestein, G.M., 1991. The pharmacokinetics of avian therapeutics. Veterinary Clinics of North America, 21, 1241–1264
Dorrestein, G.M. and Verburg, E., 1990. Pharmacokinetics of enrofloxacin in homing-pigeons. In: F. Simon, P. Lees and G. Semjén (eds), Veterinary Pharmacology, Toxicology and Therapy in Food Producing Animals, (University of Veterinary Science, Unipharma Co. Ltd, Budapest), 27–30
Flammer, K., Aucoin, D.P. and Whitt, D.A., 1991. Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses. Journal of Veterinary Pharmacology and Therapeutics, 14, 359–366
Froyman, R., Scheer, M. and De Jong, A., 1994. Serum kinetics of enrofloxacin in Pekin ducks during drinking-water medication and Baytril 10% oral solution. In: Proceedings of the Sixth International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, (Blackwell Scientific, Oxford), 236–237
Gibaldi, M. and Perrier, D., 1982. Pharmacokinetics, 2nd edn, (Marcel Dekker, New York), 409–457
Gicquel, M., Renard, L., Laurentie, M. and Sanders, P., 1994. Pharmacodynamic model of antimicrobial activity of enrofloxacin and ciprofloxacin. In: Proceedings of the Sixth International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, (Blackwell Scientific, Oxford), 229–230
Hooper, D.C. and Wolfson, J.S., 1991. Fluoroquinolone antimicrobial agents. New England Journal of Medicine, 7, 384–394
Kung, K., Riond, I.-L. and Wanner, M., 1993. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 16, 462–468
Richez, P., Dellac, B. and Froyman, R., 1994. Pharmacokinetics and bioavailability of enrofloxacin in pigs after single and repeated in-feed medication with Baytril L.F.R. 2.5%. In: Proceedings of the Sixth International Congress of the European Association for Veterinary Pharmacology and Toxicology, Edinburgh, 1994, (Blackwell Scientific, Oxford), 207–208
Scheer, M., 1987a. Concentrations of active ingredient in the serum and in tissues after oral and parenteral administration of Baytril. Veterinary Medicine Review, 2, 104–118
Scheer, M., 1987b. Studies on the antimicrobial activity of Baytril. Veterinary Medicine Review, 2, 90–99
Scheer, M., 1990. Enrofloxacin (Baytril) microbiological profile and pharmacokinetics in several species of animal. In: F. Simon, P. Lees and G. Semjén (eds), Veterinary Pharmacology, Toxicology and Therapy in Food Producing Animals, (University of Veterinary Science, Unipharma Co. Ltd, Budapest), 15–20
Stipkovits, L., 1988. Studies on the efficacy of Baytril in chicks after experimental infection with Mycoplasma gallisepticum and E. coli. Veterinary Medicine Review, 59, 103–107
Tyczkowska, K., Hedeen, K.M., Aucoin, D.P. and Aronson, A.L., 1989. High performance liquid chromatographic method for the simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in canine serum and prostatic tissue. Journal of Chromatography, 493, 337–346
Winer, B.J., 1971. In: Statistical Principles in Experimental Design, 2nd edn, (McGraw-Hill, New York), 201–205
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Intorre, L., Mengozzi, G., Bertini, S. et al. The Plasma Kinetics and Tissue Distribution of Enrofloxacin and its Metabolite Ciprofloxacin in the Muscovy Duck. Vet Res Commun 21, 127–136 (1997). https://doi.org/10.1023/A:1005773603905
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DOI: https://doi.org/10.1023/A:1005773603905