Abstract
We measure EGF in saliva and plasma from 52 patients with active breast cancer, 22 breast cancer patients in follow-up (non-active) and 33 healthy women. EGF concentrations in saliva were significantly higher in patients with active and non-active breast cancer than healthy women, whereas the opposite results were found in plasma. The highest values of EGF in saliva were found in the local recurrence subgroup.
Similar content being viewed by others
References
James R, Bradshaw BA: Polypeptide growth factors. Ann Rev Biochem 48: 259–289, 1979
Dickson RB, Lippman ME: Molecular determinants of growth, angiogenesis and metastases in breast cancer. Semin Oncol 19: 286–298, 1992
McKay IA: Types of growth factor activity: detection and characterization of new growth factor activities. In: McKay IA, Leigh I (eds) Growth factors, a practical approach. New York, IRL Press, 1993, pp 1–11
Green H: Terminal differentiation of cultured human epidermal cells. Cell 111: 405–410, 1977
Fisher DA, Lakshmanan J: Metabolism and effects of epidermal growth factor and related growth factors in mammals. Endocr Rev 11: 418–442, 1990
Brown CF, Teng CT, Pentecost BT et al: Epidermal growth factor precursor in mouse lactating mammary gland alveolar cells. Mol Endocrinol 3: 1077–1089, 1989
Elder JB, Williams G, Lacey E et al: Cellular localization of human urogastrone/epidermal growth factor. Nature 271: 466–467, 1978
Konturek JW, Bielanski W, Konturek SJ et al: Distribution and release of epidermal growth factor in man. Gut 30: 1194–1200, 1989
Klijn JGM, Berns PMJJ, Schmitz PIM et al.: The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: A review on 5232 patients. Endocr Rev 13: 3–17, 1992
Bolufer P, Lluch A, Molina R et al.: Epidermal growth factor in human breast cancer, endometrial cancer and lung cancer. Its relationship to epidermal growth factor receptor, estradiol receptor and tumor TNM. Clin Chim Acta 215: 51–61, 1993
Hermanek P, Sobin LH: TNM Classification of Malignant Tumours: UICC International Union Against Cancer (4th ed.). Berlin, Springer-Verlag, 1987
Smith K, Miller WR, Fennelly JA: Quantification of epidermal growth factor in human breast cyst fluids: Correlation with dehydroepiandrosterone-sulphate and electrolyte concentrations. Int J Cancer 44: 229–232, 1989
Papaioannou AN: Hypothesis: Increasingly intensive locoregional treatment of breast cancer may promote recurrence. J Surg Oncol 30: 33–41, 1985
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Navarro, M.A., Mesía, R., Díez-Gibert, O. et al. Epidermal growth factor in plasma and saliva of patients with active breast cancer and breast cancer patients in follow-up compared with healthy women. Breast Cancer Res Treat 42, 83–86 (1997). https://doi.org/10.1023/A:1005755928831
Issue Date:
DOI: https://doi.org/10.1023/A:1005755928831