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Glucocorticoid-induced long-term remission in primary cerebral lymphoma: case report and review of the literature


We report a 25-year old immunocompetent woman with a high grade primary non-Hodgkin‘s lymphoma of the central nervous system (PNHL-CNS) in whom the administration of dexamethasone alone during three months produced a complete clinical and radiological response lasting over four years. If complete remission of PNHL-CNS induced by glucocorticoids are well known, the opportunity to observe glucocorticoid-induced remission for a long period oftime without radio- and chemotherapy is rare. Only nine othercases of PNHL-CNS with complete remission induced by glucocorticoidslasting from 6 to 60 months, were found in the literature and aresummarized here. Duration of glucocorticoids therapeutic effect inPNHL-CNS is probably underestimated. Glucocorticoids cannotbe recommended as sole initial treatment for PNHL-CNS. However, we suggest standard therapies to be delayed in thosepatients responding completely to glucocorticoids where radio-and chemotherapy should be contraindicated (kidney, liver, bonemarrow failure, pregnancy).

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Pirotte, B., Levivier, M., Goldman, S. et al. Glucocorticoid-induced long-term remission in primary cerebral lymphoma: case report and review of the literature. J Neurooncol 32, 63–69 (1997).

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  • central nervous system
  • brain neoplasm
  • non-Hodgkin‘s lymphoma
  • brain lymphoma
  • glucocorticoids