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Monte Carlo simulation of biospecific interactions

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Abstract

Numerical simulations of the stochastic time evolution of biospecific interactions are described and show that when molecular populations are large, time course predictions match those obtained using a deterministic expression. When population size is decreased the effects of stochastic noise become apparent. The significance of stochastic noise in sensitive binding-based assay systems suggests an immediate need for models of this type.

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Bath, Claverton Down, Bath, BA2 7AY, UK

    John Hubble

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  1. John Hubble
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Hubble, J. Monte Carlo simulation of biospecific interactions. Biotechnology Letters 22, 1483–1486 (2000). https://doi.org/10.1023/A:1005684225609

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  • DOI: https://doi.org/10.1023/A:1005684225609

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