For cosmetic applications, papain or lysozyme was conjugated to a soluble biopolymer produced by Schizophyllum commune. Stability of the conjugated enzymes were significantly enhanced, such that more than 90% of the initial activity remained after a month storage at 45 °C, even in a cosmetic formulation including various oils and surfactants. Cosmetic lotion containing 1% papain conjugate was more effective in exfoliating stratum corneum of skin than the lotion containing 5% lactic acid, one of the popular exfoliating agents.
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Sim, YC., Lee, SG., Lee, DC. et al. Stabilization of papain and lysozyme for application to cosmetic products. Biotechnology Letters 22, 137–140 (2000). https://doi.org/10.1023/A:1005670323912