REFERENCES
Hammond JW, Potter M, Wilcken B, Truscott R (1995) Siblings with c-glutamyltransferase deficiency. J Inherit Metab Dis 18:82–83.
Jakobsson P-J, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B (1999) Common structural features of MAPEG-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. Protein Sci 8:689–692.
Lammers CH, Schweitzer P, Facchinetti P, et al (1996) Arachidonate 5–lipoxygenase and its activating protein: prominent hippocampal expression and its role in somatostatin signaling. J Neurochem 66:147–152.
Lindgren JA, Hökfelt T, Dahlén SE, Patrono C, Samuelsson B (1984) Leukotrienes in the rat central nervous systems. Proc Natl Acad Sci USA 81:6212–6216.
Mayatepek E, Ho.mann GF (1995) Leukotrienes: biosynthesis, metabolism and pathophysiological significance. Pediatr Res 37:1–9.
Mayatepek E, Flock B (1998) Leukotriene deficiency: a new inborn error of C4–synthesis metabolism linked to a fatal developmental syndrome. Lancet 352:1514–1517.
Mayatepek E, Lindner M, Zelezny R, Lindner W, Brandstetter G, Ho.mann GF (1999) A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene deficiency is new neurometabolic disorder. Neuro-C4–synthesis pediatrics 30:5–7.
Miyamato T, Lindgren JA, Hökfelt T, Samuelsson B (1987) Regional distribution of leukotriene and monohydroxyeicosanoic acid production in the rat brain. FEBS Lett 216:123–127.
Samuelsson B, Dahleén SE, Lindgren JA, Rouzer CA, Serhan CN (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237:1171–1176.
Simmet T, Luck W, Delank WK, Peskar BA (1988) Formation of cysteinyl leukotrienes by human brain tissue. Brain Res 456:344–349.
Spector R, Goetzl EL (1986) Role of concentrative leukotriene transport systems in the central nervous system. Biochem Pharmacol 35:2849–2853.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mayatepek, E., Zelezny, R., Lehmann, W.D. et al. Defects in the synthesis of cysteinyl leukotrienes: A new group of inborn errors of metabolism. J Inherit Metab Dis 23, 404–408 (2000). https://doi.org/10.1023/A:1005664204956
Issue Date:
DOI: https://doi.org/10.1023/A:1005664204956