Journal of Bioenergetics and Biomembranes

, Volume 32, Issue 3, pp 247–258 | Cite as

The Human Nm23/Nucleoside Diphosphate Kinases

  • Marie-Lise Laurence Lacombe
  • Annie Munier
  • James G. Mehus
  • David O. Lambeth


Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes phosphoryl transfer from a nucleoside triphosphate toa nucleoside diphosphate, is ubiquitously found in organisms from bacteria to human. Overthe past 10 years, eight human genes of the nm23/NDP kinase family have been discoveredthat can be separated into two groups based on analysis of their sequences. In addition tocatalysis, which may not be exhibited by all isoforms, evidence for regulatory roles has comerecently from the discovery of the genes nm23 and awd, which encode NDP kinases and areinvolved in tumor metastasis and Drosophila development, respectively. Current work showsthat the human NDP kinase genes are differentially expressed in tissues and that their productsare targeted to different subcellular locations. This suggests that Nm23/NDP kinases possessdifferent, but specific, functions within the cell, depending on their localization. The roles ofNDP kinases in metabolic pathways and nucleic acid synthesis are discussed.

Nm23 NDP kinase mitochondria testis dynein metastasis 


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© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Marie-Lise Laurence Lacombe
    • 1
    • 2
  • Annie Munier
    • 2
  • James G. Mehus
    • 3
  • David O. Lambeth
    • 4
  1. 1.Faculté de Médecine Saint-AntoineINSERM U402ParisFrance
  2. 2.Faculté de Médecine Saint-AntoineINSERM U402ParisFrance
  3. 3.Department of Biochemistry and Molecular BiologyUniversity of North Dakota School of Medicine and Health SciencesGrand Forks
  4. 4.Department of Biochemistry and Molecular BiologyUniversity of North Dakota School of Medicine and Health SciencesGrand Forks

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