Journal of Bioenergetics and Biomembranes

, Volume 32, Issue 3, pp 247–258 | Cite as

The Human Nm23/Nucleoside Diphosphate Kinases

  • Marie-Lise Laurence Lacombe
  • Annie Munier
  • James G. Mehus
  • David O. Lambeth
Article

Abstract

Biochemical experiments over the past 40 years have shown that nucleoside diphosphate(NDP) kinase activity, which catalyzes phosphoryl transfer from a nucleoside triphosphate toa nucleoside diphosphate, is ubiquitously found in organisms from bacteria to human. Overthe past 10 years, eight human genes of the nm23/NDP kinase family have been discoveredthat can be separated into two groups based on analysis of their sequences. In addition tocatalysis, which may not be exhibited by all isoforms, evidence for regulatory roles has comerecently from the discovery of the genes nm23 and awd, which encode NDP kinases and areinvolved in tumor metastasis and Drosophila development, respectively. Current work showsthat the human NDP kinase genes are differentially expressed in tissues and that their productsare targeted to different subcellular locations. This suggests that Nm23/NDP kinases possessdifferent, but specific, functions within the cell, depending on their localization. The roles ofNDP kinases in metabolic pathways and nucleic acid synthesis are discussed.

Nm23 NDP kinase mitochondria testis dynein metastasis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. Adams, V., Bosch, W., Schlegel, J., Wallimann, T., and Brdiczka, D. (1989). Biochim. Biophys. Acta. 981, 213-225.Google Scholar
  2. Adams, V., Griffin, L., Towbin, J., Gelb, B., Worley, K., and McCabe, E. R. (1991). Biochem. Med. Metab. Biol. 45 , 271-291.Google Scholar
  3. Amendola, R., Martinez, R., Negroni, A., Venturelli, D., Tanno, B., Calabretta, B., and Raschella, G. (1997). J. Natl. Cancer Inst. 89, 1300-1310.Google Scholar
  4. Arora, K. K., and Pedersen, P. L. (1988). J. Biol. Chem. 263, 17422-17428.Google Scholar
  5. Backer, J. M., Mendola, C. E., Kovesdi, I., Fairhurst, J. L., O'Hara, B., Eddy, R. L., Jr., Shows, T. B., Mathew, S., Murty, V. V., and Chaganti, R. S. (1993). Oncogene 8, 497-502.Google Scholar
  6. Barraud, P., Amrein, L., Dobremez, E., Dabernat, S., Massé, K., Larou, M., Daniel, J. Y., and Landry, M. (1999). Proc. 3rd Intern. Congr. Genet Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. P1.Google Scholar
  7. Berg, P., and Joklik, W. K. (1953). Nature (London) 172, 1008-1009.Google Scholar
  8. Bessman, S. P., and Carpenter, C. L. (1985). Annu. Rev. Biochem., 831-862.Google Scholar
  9. Biggs, J., Tripoulas, N., Hersperger, E., Dearolf, C., and Shearn, A. (1988). Genes Develop. 2, 1333-1343.Google Scholar
  10. Biggs, J., Hersperger, E., Steeg, P. S., Liotta, L. A., and Shearn, A. (1990). Cell 63, 933-940.Google Scholar
  11. Brdiczka, D., Beutner, G., Ruck, A., Dolder, M., and Wallimann, T. (1998). Biofactors. 8, 235-242.Google Scholar
  12. Cheng, Y. C., Agarwal, R. P, and Parks, R. E., Jr. (1971). Biochemistry. 10, 2139-2143.Google Scholar
  13. Cheng, Y. C., Robison, B., and Parks, R. E., Jr. (1973). Biochemistry. 12, 5-10.Google Scholar
  14. Chiadmi, M., Morera, S., Lascu, I., Dumas, C., Le Bras, G., Veron, M., and Janin, J. (1993). Structure 1, 283-293.Google Scholar
  15. Dearolf, C. R., Hersperger, E., and Shearn, A. (1988). Develop.Biol. 129, 159-168.Google Scholar
  16. Dooley, S., Seib, T., Engel, M., Theisinger, B., Janz, H., Piontek, K., Zang, K. D., and Welter, C. (1994). Human Genet. 93, 63-66.Google Scholar
  17. Dzeja, P. P., Zeleznikar, R. J., and Goldberg, N. D. (1998). Mol. Cell Biochem. 184, 169-182.Google Scholar
  18. Engel, M., Seifert, M., Theisinger, B., Seyfert, U., and Welter, C. (1998). J. Biol. Chem. 273, 20058-20065.Google Scholar
  19. Erent, M., Gonin, P., Tissier, P., Cherfils, J., Giartoso, A., Konrad, M., Sarger, C., and Lascu, I. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T21.Google Scholar
  20. Escobar Galvis, M. L., Hakansson, G., Alexciev, K., and Knorpp, C. (1999). Biochimie 81, 1089-1096.Google Scholar
  21. Fearon, E. R. (1997). Science 278, 1043-1050.Google Scholar
  22. Fukuchi, T., Nikawa, J., Kimura, N., and Watanabe, K. (1993). Gene 129, 141-146.Google Scholar
  23. Gervasi, F., D'Agnano, I., Vossio, S., Zupi, G., Sacchi, A., and Lombardi, D. (1996). Cell Growth Different. 7, 1689-1695.Google Scholar
  24. Gilles, A. M., Presecan, E., Vonica, A., and Lascu, I. (1991). J. Biol. Chem. 266, 8784-8789.Google Scholar
  25. Glaze, R. P., and Wadkins, C. L. (1967). J. Biol. Chem. 242, 2139-2150.Google Scholar
  26. Gonin, P., Xu, Y., Milon, L., Dubernat, S., Morr, M., Kumar, R., Lacombe, M. L., Janin, J., and Lascu, I. (1999). Biochemistry 38, 7265-7272.Google Scholar
  27. Green, D., and Kroemer, G. (1998). Trends Cell Biol. 8, 267-271.Google Scholar
  28. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988). Science 241, 42-52.Google Scholar
  29. Herbert, E., Potter, V. R., and Takagi, Y. (1955). J. Biol. Chem. 213, 923-940.Google Scholar
  30. Howlett, A. R., Petersen, O. W., Steeg, P. S., and Bissell, M. J. (1994). J. Natl. Cancer Inst. 86, 1838-1844.Google Scholar
  31. Ishijima, Y., Shimada, N., Fukuda, M., Miyazaki, H., Orlov, N. Y. Orlova, T. G., Yamada, T., and Kimura, N. (1999). FEBS Lett. 445, 155-159.Google Scholar
  32. Izumiya, H., and Yamamoto, M. (1995). J. Biol. Chem. 270, 27859-27864.Google Scholar
  33. Jacobus, W. E., and Evans, J. J. (1977). J. Biol. Chem. 252, 4232-4241.Google Scholar
  34. Johnson, J. D., Mehus, J. G., Tews, K., Milavetz, B. I., and Lambeth, D. O. (1998a). J. Biol. Chem. 273, 27580-27586.Google Scholar
  35. Johnson, J. D., Muhonen, W. W., and Lambeth, D. O. (1998b). Biol. Chem. 273, 27573-27579.Google Scholar
  36. Keim, D., Hailat, N., Melhem, R., Zhu, X. X., Lascu, I., Veron, M., Strahler, J., and Hanash, S. M. (1992). J. Clin. Invest. 89, 919-924.Google Scholar
  37. Kimura, N. (1993). In Handbook of Experimental Pharmacology, Vol.108/II, Chap. 74. Springer-Verlag, Berlin, pp. 485-498.Google Scholar
  38. Kimura, N., and Shimada, N. (1988). J. Biol. Chem. 263, 4647-4653.Google Scholar
  39. Kimura, N, Shimada, N., Nomura, K., and Watanabe, K. (1990). J. Biol. Chem. 265, 15744-15749.Google Scholar
  40. Kraeft, S. K., Traincart, F., Mesnildrey, S., Bourdais, J., Veron, M., and Chen, L. B. (1996). Exp. Cell Res. 227, 63-69.Google Scholar
  41. Krebs H. A., and Hems, R. (1953). Biochem. Biophys. Acta. 12, 172-180.Google Scholar
  42. Lacombe, M. L., Wallet, V., Troll, H., and Veron, M. (1990). J. Biol. Chem. 265, 10012-10018.Google Scholar
  43. Lakso, M., Steeg, P. S., and Westphal, H. (1992). Cell Growth Different. 3, 873-879.Google Scholar
  44. Lambeth, D. O., Frohlich, D. A., Kelly, J., and Adkins, S. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/ Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. P9.Google Scholar
  45. Lambeth, D. O., Mehus, J. G., Ivey, M. A., and Milavetz, B. I. (1997). J. Biol. Chem. 272, 24604-24611.Google Scholar
  46. Lascu, I., Chaffotte, A., Limbourg-Bouchon, B., and Veron, M. (1992). J. Biol. Chem. 267, 12775-12781.Google Scholar
  47. Lee, H., Okada, K., Baba, H., Furukawa, K., Chang, S. I; and Shiku, H. (1997). Intern. J. Oncol. 11, 965-970.Google Scholar
  48. Leung, S. M., and Hightower, L. E. (1997). J. Biol. Chem. 272, 2607-2614.Google Scholar
  49. Levit, M. N., Postel, E. H., and Stock J. B. (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T34Google Scholar
  50. Lombardi, D., Lacombe, M. L., and Paggi, M. (2000). J. Cell Physiol. 182, 144-149.Google Scholar
  51. Lu, Q., Zhang, X., Almaula, N., Mathews, C. K., and Inouye, M. (1995) J. Mol. Biol. 254, 337-341.Google Scholar
  52. Martinez, R, Venturelli, D, Perrotti, D., Veronese, M. L., Kastury, K., Druck, T., Huebner, K., and Calabretta, B. (1997). Cancer Res. 57, 1180-1187.Google Scholar
  53. Marzo, I., Brenner, C., Zamzami, N., Jurgensmeier, J. M., Susin, S. A., Vieira, H. L, Prevost, M. C., Xie, Z., Matsuyama, S., Reed, J. C., and Kroemer, G. (1998). Science 281, 2027-2031.Google Scholar
  54. Mehus, J. G., Deloukas, P., and Lambeth, D. O. (1999). Human Genet. 104, 454-459.Google Scholar
  55. Mehus, J. G., and Lambeth, D. O (1999). Proc. 3rd Intern. Congr. Genet. Biochem. Physiol. Nm23/Nucleoside Diphosphate Kinase, Bordeaux, France, Abstr. T24.Google Scholar
  56. Milon, L., Meyer, P., Chiadmi, M., Munier, A., Johansson, M., Karlsson, A., Lascu, I., Capeau, J., Janin, J., and Lacombe, M. L. (2000). J. Biol. Chem. 275, 14264-14272.Google Scholar
  57. Milon, L., Rousseau-Merck, M. F., Munier, A., Erent, M., Lascu, I., Capeau, J., and Lacombe, M. L. (1997). Human Genet. 99, 550-557.Google Scholar
  58. Min, K., Kim, S. Y., Song, H. K., Chang, C., Cho, S. J., Moon, J., Yang, J. K., Lee, J. Y., Lee, K. J. and Suh, S. W. (2000). Acta Crystallogr D56, 503-504Google Scholar
  59. Moréra, S., Lacombe, M. L., Xu, Y., LeBras, G., and Janin, J. (1995). Structure 3, 1307-1314.Google Scholar
  60. Muhonen, W. W., and Lambeth, D. O. (1995). Comp. Biochem. Physiol. B Biochem. Mol. Biol. 110, 211-23.Google Scholar
  61. Munier, A., Feral, C., Milon, L., Pinon, V. P., Gyapay, G., Capeau, J., Guellaen, G., and Lacombe, M. L. (1998). FEBS Lett. 434, 289-294.Google Scholar
  62. Munoz-Dorado, J., Inouye, M., and Inouye, S. (1990). J. Biol. Chem. 265, 2702-2706.Google Scholar
  63. Neupert, W. (1997). Annu. Rev. Biochem. 66, 863-917.Google Scholar
  64. Nickerson, J. A., and Wells, W. W. (1984). J. Biol. Chem. 259, 11297-11304.Google Scholar
  65. Ogawa, K., Takai, H., Ogiwara, A., Yokota, E., Shimizu, T., Inaba, K., and Mohri, H. (1996). Mol. Biol. Cell 7, 1895-1907.Google Scholar
  66. Okabe-Kado, J., Kasukabe, T., Hozumi, M., Honma, Y., Kimura, N., Baba, H., Urano, T., and Shiku, H. (1995). FEBS Lett 24, 311-315.Google Scholar
  67. Otero, A. de S. (1997). J. Biol. Chem. 275, 14690-14694.Google Scholar
  68. Ottaway, J. H., McClellan, J. A., and Saunderson, C. L. (1981). Intern. Biochem. 13, 401-410.Google Scholar
  69. Ouatas, T., Abdallah, B., Gasmi, L., Bourdais, J., Postel, E., and Mazabraud, A. (1997). Gene 194, 215-225.Google Scholar
  70. Pedersen, P. L. (1973). J. Biol. Chem. 248, 3956-3962.Google Scholar
  71. Pinon, V. P., Millot, G., Munier, A., Vassy, J., Linares-Cruz, G., Capeau, J., Calvo, F., and Lacombe, M. L. (1999). Exp. Cell Res. 246, 355-367.Google Scholar
  72. Prem veer Reddy, G., and Pardee, A. B. (1980). Proc. Natl. Acad. Sci. USA 77, 3312-3316.Google Scholar
  73. Ray, N. B., and Mathews, C. K. (1992). Current Topics Cell Reg. 33, 343-357.Google Scholar
  74. Reymond, A., Volorio, S., Merla, G., Al-Maghtheh, M., Zuffardi, O., Bulfone, A., Ballabio, A., and Zollo M. (1999). Oncogene 18, 7244-7252.Google Scholar
  75. Rosengard, A. M., Krutzsch, H. C., Shearn, A., Biggs, J. R., Barker, E., Margulies, I. M., King, C. R., Liotta, L. A., and Steeg, P. S. (1989). Nature (London) 342, 177-180.Google Scholar
  76. Sastre-Garau, X., Ovtracht, L., Lascu, I., Lacombe, M. L., Veron, M., Bourdache, K., and Thiery, J. P. (1992). Bull Cancer 79, 465-470.Google Scholar
  77. Schaertl, S., Geeves, M. A., and Konrad, M. (1999). J. Biol. Chem. 274, 20159-20164.Google Scholar
  78. Shimizu, S., Narita, M., and Tsujimoto, Y. (1999). Nature (London) 399, 483-487.Google Scholar
  79. Shingyoji, C., Higuchi, H., Yoshimura, M., Katayama, E., and Yanagida, T. (1998). Nature (London) 393, 711-714.Google Scholar
  80. Sonnemann, J., and Mutzel, R. (1995). Biochem. Biophys. Res. Commun. 209, 490-496.Google Scholar
  81. Stahl, J. A., Leone, A., Rosengard, A. M., Porter, L., King, C. R., and Steeg, P. S. (1991). Cancer Res. 51, 445-449.Google Scholar
  82. Steeg, P. S., Bevilacqua, G., Kopper, L., Thorgeirsson, U. P., Talmadge, J. E., Liotta, L. A., and Sobel, M. E. (1988). J. Natl. Cancer Inst. 80, 200-204.Google Scholar
  83. Traut, T. W. (1994). Mol. Cell Biochem. 140, 1-22.Google Scholar
  84. Troll, H., Winckler, T., Lascu, I., Muller, N., Saurin, W., Veron, M., and Mutzel, R. (1993). J. Biol. Chem. 268, 25469-25475.Google Scholar
  85. Tsuiki, H., Nitta, M., Furuya, A., Hanai, N., Fujiwara, T., Inagaki, M., Kochi, M., Ushio, Y., Saya, H., and Nakamura, H. (1999). J. Cell Biochem. 76, 254-269.Google Scholar
  86. Urano, T., Takamiya, K., Furukawa, K., and Shiku, H. (1992).. FEBS Lett. 309, 358-362.Google Scholar
  87. Varesco, L., Caligo, M. A., Simi, P., Black, D. M., Nardini, V., Casarino, L., Rocchi, M., Ferrara, G., Solomon, E., and Bevilacqua, G. (1992). Genes Chromosomes Cancer 4, 84-88.Google Scholar
  88. Venturelli, D., Martinez, R., Melotti, P., Casella, I., Peschle, C., Cucco, C., Spampinato, G., Darzynkiewicz, Z., and Calabretta, B. (1995). Proc. Natl. Acad. Sci. USA 92, 7435-7439.Google Scholar
  89. Wallet, V., Mutzel, R., Troll, H., Barzu, O., Wurster, B., Veron, M., and Lacombe, M. L. (1990). J. Natl. Cancer Inst. 82, 1199-1202.Google Scholar
  90. Wagner, P. D., and Vu, N. D. (2000). Biochem. J. 346, 623-630.Google Scholar
  91. Webb, P. A., Perisic, O., Mendola, C. E., Backer, J. M., and Williams, R. L. (1995). J. Mol. Biol. 251, 574-587.Google Scholar
  92. Willems, R., Van Bockstaele, D. R., Lardon, F., Lenjou, M., Nijs, G., Snoeck, H. W., Berneman, Z. N., and Slegers, H. (1998). J. Biol. Chem. 273, 13663-13668.Google Scholar
  93. Yamashiro, S., Urano, T., Shiku, H., and Furukawa, K. (1994). Oncogene 9, 2461-8.Google Scholar
  94. Yelick, P. C., Kwon, Y. H., Flynn, J. F., Borzorgzadeh, A., Kleene, K.C., and Hecht, N. B. (1989). Mol. Reprod. Develop. 1, 193-200.Google Scholar
  95. Zhang, X., Lu, Q., Inouye, M., and Mathews, C. K. (1996). J. Bacteriol. 178, 4115-4121.Google Scholar
  96. Zhu, J., Tseng, Y. H., Kantor, J. D., Rhodes, C. J., Zetter, B. R., Moyers, J. S., and Kahn, C. R. (1999). Proc. Natl. Acad. Sci. USA 96, 14911-14918.Google Scholar

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Marie-Lise Laurence Lacombe
    • 1
    • 2
  • Annie Munier
    • 2
  • James G. Mehus
    • 3
  • David O. Lambeth
    • 4
  1. 1.Faculté de Médecine Saint-AntoineINSERM U402ParisFrance
  2. 2.Faculté de Médecine Saint-AntoineINSERM U402ParisFrance
  3. 3.Department of Biochemistry and Molecular BiologyUniversity of North Dakota School of Medicine and Health SciencesGrand Forks
  4. 4.Department of Biochemistry and Molecular BiologyUniversity of North Dakota School of Medicine and Health SciencesGrand Forks

Personalised recommendations