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Unphosphorylated crossbridges and latch: smooth muscle regulation revisited

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References

  • Bárány M (1996) Biochemistry of Smooth Muscle Contraction. Academic Press, San Diego, CA.

    Google Scholar 

  • Adelstein RS and Conti MA (1975) Phosphorylation of platelet myosin increases actin-activated myosin ATPase activity. Nature 256: 597-598.

    Google Scholar 

  • Chacko S and Eisenberg E (1990) Cooperativity of actin-activated ATPase of gizzard heavy meromyosin in the presence of gizzard tropomyosin. J Biol Chem 265: 2105-2110.

    Google Scholar 

  • Guilford WH, Dupuis DE, Kennedy G, Wu JR, Patlak JB and Warshaw DM (1997) Smooth muscle and skeletal muscle myosins produce similar unitary forces and displacements in the laser trap. Biophys J 72: 1006-1021.

    Google Scholar 

  • Haeberle JR (1999) Thin-filament linked regulation of smooth muscle myosin. J Muscle Res Cell Motil 20: 363-370.

    Google Scholar 

  • Haeberle JR (1994) Calponin decreases the rate of cross-bridge cycling and increases maximum force production by smooth muscle myosin in an in vitro motility assay. J Biol Chem 269: 12424-12431.

    Google Scholar 

  • Haeberle JR and Hemric ME (1995) Are actin filaments moving under unloaded conditions in the in vitro motility assay. Biophys J 68(Suppl.) 306S-311S.

    Google Scholar 

  • Haeberle JR, Trybus KM, Hemric ME and Warshaw DM (1992) The effects of smooth muscle caldesmon on actin filament motility. J Biol Chem 267: 23001-23006.

    Google Scholar 

  • Molloy JE, Burns JE, Kendrick-jones J, Tregear, RT and White DCS (1995) Movement and force produced by a single myosin head. Nature 378: 209-212.

    Google Scholar 

  • Rembold CM and Murphy RA (1986) Myoplasmic calcium, myosin phosphorylation, and regulation of the crossbridge cycle in swine arterial smooth muscle. Circulation Res 58: 803-815.

    Google Scholar 

  • Rovner AS, Freyzon Y and Trybus KM (1995) Chimeric substitutions of the actin-binding loop activate dephosphorylated but not phosphorylated smooth muscle heavy meromyosin. J Biol Chem 270: 30260-30263.

    Google Scholar 

  • Sellers JR and Adelstein RS (1985) The mechanism of regulation of smooth muscle myosin by phosphorylation. Curr Top Cell Regul 27: 51-62.

    Google Scholar 

  • Sellers JR and Adelstein RS (1987) Regulation of contractile activity. In: Boyer PD (ed.), The Enzymes (pp. 381-418). Academic Press, Orlando. FL.

    Google Scholar 

  • Sellers JR, Eisenberg E and Adelstein RS (1982) The binding of smooth muscle heavy meromyosin to actin in the presence of ATP. Effect of phosphorylation. J Biol Chem 257: 13880-13883.

    Google Scholar 

  • Somlyo AV, Goldman YE, Fujimori T, Bond M, Trentham DR and Somlyo AP (1988) Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study. J Gen Physiol 91: 165-192.

    Google Scholar 

  • Trybus KM (1989) Filamentous smooth muscle myosin is regulated by phosphorylation. J Cell Biol 109: 2887-2894.

    Google Scholar 

  • Vanburen P, Work SS and Warshaw DM (1994) Enhanced force generation by smooth muscle myosin in vitro. Proc Natl Acad Sci USA 91: 202-205.

    Google Scholar 

  • Wagner PD and Vu ND(1986) Regulation of the actin-activated ATPase of aorta smooth muscle myosin. J Biol Chem 261: 7778-7783.

    Google Scholar 

  • Wagner PD and Vu ND (1987) Actin-activation of unphosphorylated gizzard myosin. J Biol Chem 262: 15556-15562.

    Google Scholar 

  • Walsh MP, Bridenbaugh R, Kerrick WG and Hartshorne DJ (1983) Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory. Fed Proc 42: 45-50.

    Google Scholar 

  • Warshaw DM, Desrosiers JM, Work SS and Trybus KM (1990) Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro. J Cell Biol 111: 453-463.

    Google Scholar 

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  1. National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 8N202, Bethesda, MD, 20892-1762, USA

    James R. Sellers

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  1. James R. Sellers
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Sellers, J.R. Unphosphorylated crossbridges and latch: smooth muscle regulation revisited. J Muscle Res Cell Motil 20, 347–349 (1999). https://doi.org/10.1023/A:1005557724418

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