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Preparation of (1S)-verbenone, aromatic and alicyclic carboxylic acids by oxidation of aldehydes, primary and secondary alcohols with Nocardia corallina

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Abstract

(lS)-Verbenone, (S)-perillyl acid, cinnamic acid, meta-nitrocinnamic acid, veratric acid and 2-naphthoic acid were prepared, at 1 mM scale, from the corresponding alcohols or aldehydes with whole cells of Nocardia corallina B-276, in yields from 19 to 71% (w/w). Similar microbiological oxidations gave poor yields with the heterocyclic alcohols: 3-pyridylmethanol, 4-flavanol and 4-chromanol.

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Authors and Affiliations

  1. Departamento Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, A.P. 23/181, México, D.F., México

    Herminia I. Pérez, Héctor Luna, Norberto Manjarrez, Aida Solís & Ma. Amelia Nuñez

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  1. Herminia I. Pérez
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  2. Héctor Luna
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  3. Norberto Manjarrez
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  4. Aida Solís
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  5. Ma. Amelia Nuñez
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Pérez, H.I., Luna, H., Manjarrez, N. et al. Preparation of (1S)-verbenone, aromatic and alicyclic carboxylic acids by oxidation of aldehydes, primary and secondary alcohols with Nocardia corallina . Biotechnology Letters 21, 855–858 (1999). https://doi.org/10.1023/A:1005513924016

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  • DOI: https://doi.org/10.1023/A:1005513924016

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