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Stereoinversion of optically active 3-pentyn-2-ol by Nocardia species

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Abstract

Nocardia fusca and Nocardia pseudosporangifera produced (R)-3-pentyn-2-ol and (S)-3-pentyn-2-ol in 24 and 72 h reaction, respectively, from (RS)-3-pentyn-2-ol, with greater than 70% molar yields through a stereoinversion reaction involving stereoselective oxidation and reduction with 3-pentyn-2-one as an intermediate.

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Authors and Affiliations

  1. Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan

    Jun Ogawa, Sheng-Xue Xie & Sakayu Shimizu

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  1. Jun Ogawa
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  2. Sheng-Xue Xie
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  3. Sakayu Shimizu
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Ogawa, J., Xie, SX. & Shimizu, S. Stereoinversion of optically active 3-pentyn-2-ol by Nocardia species. Biotechnology Letters 21, 331–335 (1999). https://doi.org/10.1023/A:1005484731976

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  • DOI: https://doi.org/10.1023/A:1005484731976

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