Digestive Diseases and Sciences

, Volume 45, Issue 3, pp 637–641 | Cite as

CASE REPORT: Immunological Aspects of Oral Desensitization in Food Allergy

  • E. Nucera
  • D. Schiavino
  • C. D'ambrosio
  • A. Stabile
  • C. Rumi
  • G. Gasbarrini
  • G. Patriarca
milk allergy desensitization ECP immunological mechanisms 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    McEwen LM: Hyposensitization. In Food Allergy and Intolerance. J Brostoff, SJ Challacombe (eds). Baillier Tindall 1988, pp 985-994Google Scholar
  2. 2.
    Bock SA: The natural history of food sensitivity. J Allergy Clin Immunol 69(2):173-177, 1982Google Scholar
  3. 3.
    Bock SA: Natural history of severe reactions to foods in young children. J Pediatr 107(5):676-680, 1985Google Scholar
  4. 4.
    Businco L, Benincori N, Cantani A, Tacconi L, Picarazzi A: Chronic diarrhea due to cow's milk allergy: A 4 to 10 years follow-up study. Ann Allergy 55(6):844-847, 1985Google Scholar
  5. 5.
    Sampson HA, Scanlon SM: Natural history of food hypersensitivity in children with atopic dermatitis. J Pediatr 115(1):23-27, 1989Google Scholar
  6. 6.
    Sheldon JM, Lovell RG, Mathews KP: Clinical Allergy. Philadelphia, WB Saunders, 1967Google Scholar
  7. 7.
    Pasteur VR, Blamountier P: Un cas d'allergie au lait avec phenomenes de grand choc chez un adulte. Semin Hop Paris 32:2841-2843, 1956Google Scholar
  8. 8.
    Goldstein GB, Heiner DC: Clinical and immunological perspectives in food sensitivity. J Allergy 46(5):270-291, 1970Google Scholar
  9. 9.
    Tuft L, Muller HL: Allergy in Children. Philadelphia, WB Saunders, 1970Google Scholar
  10. 10.
    Rowe AH, Rowe A: Food Allergy, Its Manifestation and Control, and Elimination Diets. Springfield, Charles C, Thomas, 1972Google Scholar
  11. 11.
    Shenassa MM, Perelmutter L, Gerrard DM: Desensitization to peanut. J Allergy Clin Immunol 75(1):177, 1985Google Scholar
  12. 12.
    Oppenheimer JJ, Nelson HS, Bock SA, Christensen F, Leung DYM: Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 90(2):256-262, 1992Google Scholar
  13. 13.
    Nelson HS, Conkling C, Areson J, Sampson HA, Bock SA, Leung DYM: Treatment of patients anaphylactically sensitive to peanuts with injections of peanut extract. J Allergy Clin Immunol 93(1):211, 1994Google Scholar
  14. 14.
    McEwen LM: Enzyme potentiated hyposensitization. Five cases report of patients with acute allergy. Ann Allergy 35(2):98-103, 1975Google Scholar
  15. 15.
    Fontana VJ: Practical Management of the Allergic Child. New York, Meredith, 1969Google Scholar
  16. 16.
    May CD, Remigiow L, Feldman J, Bock SA, Carr RJ: A study of serum antibodies to isolated milk proteins and ovoalbumin in infant and children. Clin Allergy 7:583, 1978Google Scholar
  17. 17.
    Poisson A, Thomas G, Jean-Landais N, Giaufre E: Accoutumance rapide par voie orale au lait de vache dans un cas d'allergie alimentare severe chez l'enfant. Rev Fr. Allergol 27(1):31-32, 1987Google Scholar
  18. 18.
    Patriarca G, Schiavino D, Nucera E, Schinco G, Milani A, Gasbarrini GB: Food allergy in children: Results of a standardized protocol for oral desensitization. Hepato-Gastroenterol 44:48, 1998Google Scholar
  19. 19.
    Hill DJ, Firer MA, Shelton MJ, Hosking CS: Manifestations of milk allergy in infancy: Clinical and immunological findings. J Pediatr 109:272-276, 1986Google Scholar
  20. 20.
    Hanson DG, Vaz NM, Maia LCS, Lynch JM: Inhibition of specific immune responses by feeding protein antigens. J Immunol 123(5):2344-2350, 1979Google Scholar
  21. 21.
    Swarbrick ET, Stokes C, Soothill JF: Absorption of antigens after oral immunization and the simultaneous induction of specific systemic tolerance. Gut 20(2):121-125, 1979Google Scholar
  22. 22.
    Kagnoff MF: Effects of antigen feeding on intestinal and systemic immune responses. III. Antigen-specific serum mediated suppression of humoral antibody responses after antigen feeding. Cell Immunol 40:186, 1978Google Scholar
  23. 23.
    Ngan J, Kind LK: Suppressor T Cells for IgE and IgG in Peyer's patches of mice tolerant by the oral administration of ovoalbumin. J Immunol 120(3):861-865, 1978Google Scholar
  24. 24.
    Borel Y, Fritsché R, Borel H, Dahlgren U, Dahlman-Höglund A, Telemo E, Hanson LA: Food allergens transformed into tolerogens. Int Arch Allergy Immunol 107:264-267, 1995Google Scholar
  25. 25.
    Romagnani S, Maggi E, Del Prete GF, Parronchi P, Macchia D, De Carli M, Piccinilli MP, Simonelli C, Almerigogna F, Giudizi MC, Biagiotti R: Regulation of human IgE synthesis and mechanisms of its deregulation in atopic subjects. Award Book 1991/M Debelic (ed). Goteborg, Pharmacia Allergy Research Foundation 1991, p 47Google Scholar
  26. 26.
    De Jong EC, Spanhaak S, Martens BPM, Kapsenberg ML, Penninks AH, Wierenga EA: Allergens, IgE, mediators, inflammatory mechanisms. J Allergy Clin Immunol 1:73-81, 1998Google Scholar
  27. 27.
    Mossman TR, Sad S: The expariding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17:138-146, 1996Google Scholar
  28. 28.
    Yan D, Zhou HR, Brooks KH, Pestka JJ: Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. Toxicology 122:145-158, 1997Google Scholar

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • E. Nucera
    • 1
  • D. Schiavino
    • 1
  • C. D'ambrosio
    • 1
  • A. Stabile
    • 1
  • C. Rumi
    • 1
  • G. Gasbarrini
    • 1
  • G. Patriarca
    • 1
  1. 1.Department of Allergology and Internal Medicine, Department of Pediatrics, and Department of HematologyUniversit`a Cattolica del S. Cuore, Facolt`a di Medicina e Chirurgia “Agostino Gemelli,”RomeItaly

Personalised recommendations