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Biotransformation of milbemycin D to milemycin G by Streptomyces lividans conferring avermectin O-methyltransferase activity

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Abstract

Avermectin O-methyltransferase gene was cloned from a cosmid clone covering the first module of polyketide synthase gene cluster of avermectin biosynthesis. Streptomyces lividans transformed with a DNA fragment containing avermectin O-methyltransferase gene efficiently convert milbemycin D to milbemycin G, indicating that biosynthetic genes of milbemycin and avermectin might complement each other. © Rapid Science Ltd. 1998

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Authors and Affiliations

  1. Department of Molecular Biology, Pusan National University, Natural Product Biosynthesis RU, Korea Research Institute of Bioscience and Biotechnology, Teajon, Korea

    Young-Soo Hong, Bang Yeon Hwang, Hang Sub Kim, Jeong-hyung Lee, Kyu-Won Kim & Jung Joon Lee

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  1. Young-Soo Hong
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  2. Bang Yeon Hwang
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  3. Hang Sub Kim
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  4. Jeong-hyung Lee
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  5. Kyu-Won Kim
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  6. Jung Joon Lee
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Hong, YS., Hwang, B.Y., Kim, H.S. et al. Biotransformation of milbemycin D to milemycin G by Streptomyces lividans conferring avermectin O-methyltransferase activity. Biotechnology Letters 20, 991–995 (1998). https://doi.org/10.1023/A:1005401229007

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