Abstract
Compound CBR004 which inhibits Ras farnesyl protein transferase, was produced by Bacillus licheniformis KCTC0372BP. Potassium phosphate and Tryptone were selected as media components for the production of CBR004 among 6 culture-variables using Plackett-Burman design. The yield of CBR004 was 0.99 g/l in a stirred fermenter at the C/N ratio of 1.87.
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Son, KH., Hong, SH., Kwon, YK. et al. Production of a Ras farnesyl protein transferase inhibitor from Bacillus licheniformis using Plackett-Burman design. Biotechnology Letters 20, 149–151 (1998). https://doi.org/10.1023/A:1005324407319
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DOI: https://doi.org/10.1023/A:1005324407319