Abstract
Using several techniques of statistical analysis, we studied in detail the extracellularly recorded background impulse activity (BA) of neuronal elements of the rat locus coeruleus (LC). Impulse trains generated by most LC neurons were stationary and demonstrated different levels of regularity; a nonstationary type of BA was observed in 17% of the neurons under study. Statistical parameters of the BA generated by LC neurons showed a wide variability. Distributions of the BA interspike intervals (ISI) of most LC neurons were characterized by more or less expressed bimodality or polymodality. Serial correlation analysis of the ISI durations both in stationary and nonstationary spike trains allowed us to differentiate five main types of the dynamics of ISI successions in the BA of LC neurons.
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REFERENCES
M. V. Khanbabyan, Noradrenergic Brain Mechanisms [in Russian], Nauka, Leningrad (1981).
E. Jodj, C. Chiang, and G. Aston-Jones, “Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons,” Neuroscience, 83, No. 1, 63-79 (1998).
M. Cenci, P. Kalen, W. M. Duan, and A. Bjorklund, “Transmitter release from transplants of fetal ventral mesencephalon or locus coeruleus in the rat frontal cortex and nucleus accumbens,” Brain Res., 641, No. 2, 225-48 (1994).
F. Abad-Alegria, “Estereotaxic troncoencefalica,” Trab. Inst. Cajal Invest. Biol., 63, No. 1, 193-224 (1971).
A. S. Amatuni, R. Sh. Sarkisyan, Z. A. Korcotyan, and A. K. Melikyan, “Background neuronal activity in the rat fastigial cerebellar nucleus,” Neirofiziologiya, 23, No. 4, 441-450 (1991).
A. A. Asratyan, D. N. Khudaverdyan, K. G. Bagdasaryan, and P. Sh. Sarkisyan, “Background neuronal activity in the nucleus supraopticus and its modifications under the influence of parathyroid hormone,” Neirofiziologiya/Neurophysiology, 31, No. 5, 404-411 (1999).
H. A. Hasratyan, “The effects of parathyroid hormone on the spontaneous activity of supraoptic nucleus neurons,” in: Second Conference of the Armenian IBRO Association [in Russian], Yerevan (1998), p. 36.
P. G. Kostyuk, “Background impulse activity of central neurons and its analysis,” in: Modern Problems of Physiology and Pathology of the Nervous System [in Russian], Meditsina, Moscow (1965), pp. 28-48.
M. N. Livanov, “Neurokinetics,” in: Problems of Modern Neurophysiology [in Russian], Nauka, Moscow (1965), pp. 37-73.
V. N. Dumenko and V. V. Sachenko, “Background activity in the acoustic cortical zone in the resting state and at a trained defensive conditioned reflex,” Neirofiziologiya, 10, No. 3, 227-238 (1978).
A. S. Amatuni, J. Rakowski, J. Tarneski, and K. R. Tarnes, “Interaction of converging peripheral and cerebellar cortical inputs on interpositus neurons of the cats,” Acta Neurobiol. Exp., 37, 375-396 (1977).
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Khudaverdyan, D.N., Asratyan, A.A., Varderesyan, I.V. et al. Analysis of the Neuronal Background Impulse Activity in the Rat Locus Coeruleus. Neurophysiology 32, 271–275 (2000). https://doi.org/10.1023/A:1005212309694
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DOI: https://doi.org/10.1023/A:1005212309694