Abstract
The conditioned defence reflex was elaborated by pair combination of direct stimulation of the motor cortex and electrocutaneous stimulation in awake nonimmobilized rabbit. This conditioning was organized mainly in the cortical part close to the stimulating electrode in the cortex. Influence of modulation of functional state on the observed phenomenon by means of application of GABA solution on the hypothetical place of the formation of the conditioning was examined. S-shaped dependence of effects on concentration of GABA solution was found. The hypothesis of the simultaneous modulation of processes of excitement and inhibition was used to analyse empirical dependences. Saturation effects (100% appearance of same alterations) were took into account. The model was suitable for description of the discovered nonlinear pharmacological modulation of physiological processes.
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References
Bellman, R.: Mathematical methods in medicine, World Scientific Publ. Co., Singapore, 1983.
Chizhenkova, R.A.: Structural-functional organization of sensorimotor cortex, Nauka, Moscow, 1986.
Chizhenkova, R.A.: GABA influence on temporary connection in neuronal populations of rabbit's sensorimotor cortex, Jurnal vysshey nervnoy deyatelnosti 37 (1987), 1054–1063.
Chizhenkova, R.A.: Pharmacological analysis of conditioning in sensorimotor cortex neurones in a model, Pav. J. Biol. Sci. 24 (1989), 11–18.
Chizhenkova, R.A.: Electrical trace processes in neuronal populations of the sensorimotor cortex, Uspekhi sovremennoy biologii 118 (1998), 109–128.
Chizhenkova, R.A. and Safroshkina, A.A.: A mathematical model of controlling conditioning with behavioral effect in neuronal populations of the motor cortex, Uspekhi sovremennoy biologii 115 (1995), 419–426.
Lakin, K.M. and Krylov, Yu.F.: Biotransformation of drugs, Meditzina Publishers, Moscow, 1981.
Mashkovsky, M.D.: Medical drugs, Meditzina Publishers, Moscow, 1996.
Obaturov, G.M.: Biophysical models for radiobiological effects, Energoatomizdat, Moscow, 1987.
Rubin, A.B., Pytyeva, N.F. and Riznichenko, G.Yu.: Kinetics of biological processes, MGU Publishers, Moscow, 1987.
State Pharmacopeia of the USSR. 11th edition. Issue 1: General methods of analysis, Meditzina Publishers, Moscow, 1987.
Whiting, P.J., McKernan, R.M. and Wafford, K.A.: Structure and pharmacology of vertebrate GABA-A receptor subtypes, Intern. Rev. Neurology 38 (1995), 95–137.
Woody, Ch.D. and Yarowsky, P.: Conditioning eyes blink using electrical stimulation of coronal-precruciate cortex, J. Neurophysiol. 32 (1972), 242–252.
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Chizhenkova, R., Safroshkina, A. Nonlinear Pharmacological Modulation of Conditioning in the Neocortex. Journal of Biological Physics 25, 235–244 (1999). https://doi.org/10.1023/A:1005131124958
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DOI: https://doi.org/10.1023/A:1005131124958