Abstract
An oxidative mechanism in the lead-induced inhibition of thyroid function with special reference to iodothyronine 5′- monodeiodinase (5′-ID) activity has been identified in the fish, Heteropneustes fossilis. Lead treatment (2.5, 5.0 and 10.0 ppm of lead nitrate/day for 30 days) enhanced tissue lipid peroxidation (LPO) and decreased the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). In addition, serum triiodothyronine (T3) concentration and hepatic 5'-ID activity were markedly decreased by 10 ppm of lead nitrate. These findings support the view that higher concentrations of lead nitrate inhibit the extrathyroidal conversion of thyroxine (T4) to T3. Moreover, oxidative stress from lead intoxication could be responsible for inhibiting 5′-ID activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aebi, H. U.: 1983, Methods in Enzymatic Analysis, Vol. III, Academic Press, New York, pp. 276.
Chaurasia, S. S., Gupta, P., Kar, A. and Maiti, P. K.: 1995, Curr. Sci. 69, 698.
Chaurasia, S. S., Gupta, P., Kar, A. and Maiti, P. K.: 1996a, Bull. Environ. Contam. Toxicol. 56, 649.
Chaurasia, S. S., Gupta, P., Kar, A. and Maiti, P. K.: 1996b, Biochem. Mol. Biol. Int. 39, 765.
Comporti, M.: 1985, Lab. Invest. 53, 599.
Eales, J. G.: 1985, Can. J. Zool. 63, 1217.
Halliwell, B. and Gutteridge, J. M. C.: 1985, in Free Radicals in Biology and Medicine, Clarendon Press, Oxford, pp. 139.
Kahl, S., Bitman, J. and Ramsey, T. S.: 1984, Domestic Animal Endocinol. 1, 419.
Katti, S. R. and Sathyanesan, A. G.: 1987, Ecotoxicol. Environ. Safety 13, 1.
Lockitch, G.: 1993, Clin. Biochem. 26, 371.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J.: 1951, J. Biol. Chem. 193, 265.
Maiti, P. K., Kar, A., Gupta, P. and Chaurasia, S. S.: 1995, Biochem. Biophys. Res Commun. 214, 905.
MacLatchy, D. L. and Eales, J. G.: 1992, Gen. Comp. Endocrinol. 86, 313.
Marklund, S. and Marklund, G.: 1974, Eur. J. Biochem. 47, 469.
Ohkawa, H., Ohishi, N. and Yagi, K.: 1979, Anal. Biochem. 95, 351.
Sies, J.: 1993, Eur. J. Biochem. 215, 213.
Skoczynska, A., Smolik, R. and Jelen, M.: 1993, Arch. Toxicol. 67, 200.
Spieler, R. E. and Weber, D. N.: 1991, Med. Sci. Res. 19, 477.
Toyoda, N., Berry, M. J., Harney, J. W. and Larsen, P. R.: 1995, J. Biol. Chem. 270, 12310.
Vandervliet, A. and Bast, A.: 1992, Chem. Biol. Interact. 85, 95.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chaurasia, S.S., Kar, A. An Oxidative Mechanism for the Inhibition of Iodothyronine 5′-Monodeiodinase Activity by Lead Nitrate in the Fish, Heteropneustes fossilis. Water, Air, & Soil Pollution 111, 417–423 (1999). https://doi.org/10.1023/A:1005099822637
Issue Date:
DOI: https://doi.org/10.1023/A:1005099822637