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Role of Glutathione-Dependent Peroxidase in Regulation of Lipoperoxide Utilization in Malignant Tumors

Biochemistry (Moscow) volume 66, pages 221–224 (2001)Cite this article

Abstract

Glutathione content, the activity of glutathione-dependent enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase), and also SOD (superoxide dismutase) and catalase were studied in human malignant tumors (uterus, breast, and ovaries) and normal tissues. Glutathione level and the activity of glutathione-dependent enzymes were 2-3 times higher in the malignant tumors than in normal tissues. A negative correlation between the level of glutathione and glutathione-dependent enzymes (glutathione peroxidase and glutathione S-transferase) in tumors and the efficacy of postoperative chemotherapy may characterize the degree of tumor resistance to chemotherapy and therefore may have prognostic value. Low SOD and catalase activity and high activity of glutathione-dependent enzymes in tumors suggest that glutathione peroxidase and glutathione S-transferase play a major role in peroxide utilization in malignant tumors.

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REFERENCES

  1. Golikov, S. N., Sanotsky, I. V., and Tiunov, L. A. (1986) General Mechanisms of Toxic Action[in Russian], Meditsina, Leningrad.

  2. Vinam, J. (ed.) (1990) Glutathione Metabolism and Physiological Functions, Boston.

  3. Meister, A. (1973) Science, 33–39.

  4. Kulinsky, V. I., and Kolesnichenko, L. S. (1990) Usp. Sovr. Biol., 110, 20–33.

    Google Scholar 

  5. Mazo, V. K. (1998) Ros. Z. Gastroenterol. Gepatol. Koloproktol., 1, 47–53.

    Google Scholar 

  6. Lankin, V. Z., Tihaze, A. K., and Belenkov, Yu. N. (2000) Kardiologiya, No. 7, 58–71.

    Google Scholar 

  7. Schwartsburd, P., and Lankin, V. (1995) Medical Oncol., 11, 101–110.

    Google Scholar 

  8. Oberley, L., and Buettner, G. (1979) Cancer Res., 39, 1141–1149.

    Google Scholar 

  9. Belousova, A. K. (1993) Molecular Biology Approaches to Tumor Chemotherapy [in Russian], VINITI, Moscow.

    Google Scholar 

  10. Beauchamp, Ch., and Fridovich, I. (1971) Anal. Biochem., 44, 276–287.

    Google Scholar 

  11. Beers, R., and Sizer, J. (1952) J. Biol. Chem., 195, 133–140.

    Google Scholar 

  12. Tietze, F. (1969) Anal. Biochem., 27, 502–522.

    Google Scholar 

  13. Yusupova, L. B. (1989) Lab. Delo, 4, 19–21.

    Google Scholar 

  14. Paglia, D., and Valentine, W. (1967) J. Lab. Clin. Med., 70, 158–169.

    Google Scholar 

  15. Habig, W., Pabst, M., and Jakoby, W. (1974) J. Biol. Chem., 249, 7130–7139.

    Google Scholar 

  16. Mikhaevitch, O., Mikhaevitch, I., and Gorodzanskaya, E. (1995) J. Exp. Clin. Canc. Res., 14, 247–253.

    Google Scholar 

  17. Gorodzanskaya, E. G., Patutko, Yu. I., and Sagaidak, I. V. (1995) Vopr. Onkol., 41, 47–51.

    Google Scholar 

  18. Lee, F., Vessey, A., Rofstad, E., Siemann, D., and Sutherland, R. (1989) Canc. Res., 49, 5244–5248.

    Google Scholar 

  19. Gorodzanskaya, E. G., Koroleva, E. Yu., Egorova, N. I., Larionova, V. B., Garin, A. M., and Kushlinsky, N. E. (1998) Byul. Eksp. Biol. Med., 125, 562–565.

    Google Scholar 

  20. Maltseva, E. L., Kurnakova, N. V., Burlakova, E. B., and Palmina, N. P. (1990) Biokhimiya, 55, 471–479.

    Google Scholar 

  21. Kalinina, E. V., Novichkova, M. D., and Komissarova, I. A. (1999) Byul. Eksp. Biol. Med., 128, 56–59.

    Google Scholar 

  22. Lankin, V. A., Tihaze, A. K., Osis, Yu. G., Vikhert, A. M., Scheve, T., and Rapoport, S. (1985) Dokl. Akad. Nauk SSSR, 281, 204–207.

    Google Scholar 

  23. Navarro, J., Obrador, E., Carretero, J., Petschen, I., Avino, J., Perez, P., and Estrela, J. (1999) Free Rad. Biol. Med., 26, 410–418.

    Google Scholar 

  24. Lankin, V. Z., and Gurevich, S. M. (1974) in Lipids in Animal and Human Bodies [in Russian], Nauka, Moscow, pp. 72–77.

  25. Menshchikova, E. B., and Zenkov, E. B. (1997) Usp. Sovr. Biol., 117, 155–171.

    Google Scholar 

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Affiliations

  1. Blokhin Cancer research center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, Moscow, 115478, Russia

    E. G. Gorodzanskaya, V. B. Larionova, G. N. Zubrikhina, N. G. Kormosh, T. V. Davydova & K. P. Laktionov

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  1. E. G. Gorodzanskaya
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  2. V. B. Larionova
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  3. G. N. Zubrikhina
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  4. N. G. Kormosh
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  5. T. V. Davydova
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  6. K. P. Laktionov
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Gorodzanskaya, E.G., Larionova, V.B., Zubrikhina, G.N. et al. Role of Glutathione-Dependent Peroxidase in Regulation of Lipoperoxide Utilization in Malignant Tumors. Biochemistry (Moscow) 66, 221–224 (2001). https://doi.org/10.1023/A:1002803901075

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  • DOI: https://doi.org/10.1023/A:1002803901075

  • glutathione
  • glutathione-dependent enzymes
  • lipid peroxidation
  • malignant tumors