Abstract
In conventional pharmacokinetics monotonic decreasing drug disposition curves are usually assumed after bolus injection. For arterial sampling starting about 1 min after dosing the resulting neglect of the initial concentration peak leads to a relative overestimation of clearance which may be approximated by the percentage of systemic drug extraction. This error can be avoided by administering the drug as a short-term infusion.
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Weiss, M. Errors in Clearance Estimation After Bolus Injection and Arterial Sampling: Nonexistence of a Central Compartment. J Pharmacokinet Pharmacodyn 25, 255–260 (1997). https://doi.org/10.1023/A:1025788214777
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DOI: https://doi.org/10.1023/A:1025788214777