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Reactivity of Tracheal Smooth Muscles in Albino Rats with Experimental Diabetes Mellitus Treated with a New Complex Compound of Oxovanadium (IV) and Isonicotinic Acid Hydrazide

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Abstract

We studied functional properties of tracheal smooth muscle cells in rats with diabetes mellitus. Reactivity of tracheal smooth muscles increased in rats with experimental alloxan-induced diabetes mellitus. A new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide affected reactivity of tracheal smooth muscles in albino rats with experimental type I diabetes mellitus. This new organic vanadium-containing compound reduced contractility of tracheal smooth muscles in rats and potentiated relaxation of smooth muscle cells in the trachea in response to exogenous nitric oxide.

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Authors and Affiliations

  1. Department of Pharmacology, Department of Pathophysiology, Kazan' State Medical University, Russia

    R. Kh. Khafiz'yanova, M. M. Minnebaev, R. M. Gallyamov, R. S. Latypov, A. R. Gosmanov & G. N. Aleeva

Authors
  1. R. Kh. Khafiz'yanova
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  2. M. M. Minnebaev
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  3. R. M. Gallyamov
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  4. R. S. Latypov
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  5. A. R. Gosmanov
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  6. G. N. Aleeva
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Correspondence to R. S. Latypov.

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Khafiz'yanova, R.K., Minnebaev, M.M., Gallyamov, R.M. et al. Reactivity of Tracheal Smooth Muscles in Albino Rats with Experimental Diabetes Mellitus Treated with a New Complex Compound of Oxovanadium (IV) and Isonicotinic Acid Hydrazide. Bulletin of Experimental Biology and Medicine 135, 573–575 (2003). https://doi.org/10.1023/A:1025433519840

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  • DOI: https://doi.org/10.1023/A:1025433519840

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