Skip to main content
SpringerLink
Log in

High-Performance Liquid Chromatographic Method for the Determination of Nimesulide in Pharmaceutical Preparations

  • Published:
Journal of Analytical Chemistry Aims and scope Submit manuscript

Abstract

A simple, rapid, and precise high-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations was proposed using Ibuprofen as an internal standard. The separation was performed on a CLC C18 (5 μm, 25 cm × 4.6 mm i.d.) column with a mobile phase consisting of an acetonitrile–0.05 M KH2PO4 buffer mixture of pH 7.00 (55 : 45, v/v). The detection was carried out at 230 nm and the linearity range was found to be 0.5–100 μg/mL. The method has been applied successfully to the determination of nimesulide in pharmaceutical formulations. The recovery values were found to be in the range of 99.23–100.13% with RSD values of less than 0.97%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Bernareggi, A., Drugs, 1993, suppl. 46, p. 64.

  2. Chang, S.F., Miller, A.M., and Ober, R.E., J. Pharm. Sci., 1977, vol. 66, no. 12, p. 1700.

    Google Scholar 

  3. Castoldi, D., Monzani, V., and Tofanetti, O., J. Chromatogr., B, 1988, vol. 69, no. 2, p. 413.

    Google Scholar 

  4. Jowarowicz, D.J., Jr., Filopowski, M.T., and Boje, K.M.K., J. Chromatogr., B, 1999, vol. 723, p. 293.

    Google Scholar 

  5. Khaska, G. and Udupa, N., J. Chromatogr., B, 1999, vol. 727, p. 241.

    Google Scholar 

  6. Carrasco-Portugal, M.C., Granasos-Soto, V., Camacho Vieyra, G.A., Perez-Vrizar, J., and Flores-Morrieto, F.J., J. Liq. Chromatogr., 2000, vol. 23, p. 2237.

    Google Scholar 

  7. Ptacek, P., Macek, J., and Klima, J., J. Chromatogr., B, 2001, vol. 758, p. 183.

    Google Scholar 

  8. Nonzioli, A., Luque, G., and Fernandez, C., J. High Resolut. Chromatogr., 1989, vol. 12, no. 6, p. 413.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Karnatak University, Dharwad, 580003, India

    B. S. Nagaralli, J. Seetharamappa, B. G. Gowda & M. B. Melwanki

Authors
  1. B. S. Nagaralli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Seetharamappa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. G. Gowda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. B. Melwanki
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nagaralli, B.S., Seetharamappa, J., Gowda, B.G. et al. High-Performance Liquid Chromatographic Method for the Determination of Nimesulide in Pharmaceutical Preparations. Journal of Analytical Chemistry 58, 778–780 (2003). https://doi.org/10.1023/A:1025095829622

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1025095829622

Keywords

Search

Navigation