Abstract
Hypotensive activity of ultralow doses of antibodies to angiotensin II and its receptors was studied on adult NISAG rats with hereditary stress-induced arterial hypertension. Antibodies to C-terminal fragment of angiotensin II receptors produced the most pronounced hypotensive effect, which was reproducible after repeated administration. These antibodies decreased systolic blood pressure by 16.40±0.62 mm Hg. The most rapid hypotensive effect was produced by affinity purified antibodies to angiotensin II: 2 h after administration of these antibodies systolic blood pressure decreased by 12.80±5.49 mm Hg. Our results indicate that combination treatment with ultralow doses of antibodies to angiotensin II and its receptors hold much promise for the use in clinical practice.
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Epstein, O.I., Martyushev, A.V., Kudryashova, D.R. et al. Hypotensive Effect of Potentiated Antibodies to Angiotensin II and AT1 Receptors. Bulletin of Experimental Biology and Medicine 135 (Suppl 7), 62–64 (2003). https://doi.org/10.1023/A:1024778613149
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DOI: https://doi.org/10.1023/A:1024778613149