Inflammation

, Volume 27, Issue 3, pp 129–135 | Cite as

Forsythia fructus Inhibits the Mast-Cell-Mediated Allergic Inflammatory Reactions

  • Mi-Sun Kim
  • Ho-Jeong Na
  • Seung-Woo Han
  • Jong-Sik Jin
  • Un-Yong Song
  • Eon-Jeong Lee
  • Bong-Keun Song
  • Seung-Heon Hong
  • Hyung-Min Kim

Abstract

Mast cells are key as effector cells in the early phase allergic inflammation and in diverse immunological and pathological processes. Forsythia fructus (F. fructus) has used as a traditional medicine for inflammatory diseases. In the present study, we determined the effect of F. fructus extracts on compound 48/80-induced paw oedema and vascular permeability in vivo. In addition, we investigated in vitro whether F. fructus has inhibitory effects on compound 48/80-induced histamine releases from rat peritoneal mast cells (RPMC), and on phorbol 12-myristate 13-acetate (PMA) plus A23187-induced tumor necrosis factor-α (TNF-α) releases from human mast cells (HMC-1). In mice orally administrered F. fructus (100 μg/g) for 1 h, compound-48/80-induced oedema and vascular permeability were significantly reduced rather than those receiving intravenous injection of ketotifen, mast cell stabilizer. F. fructus dose-dependently inhibited the histamine release induced by compound 48/80 from RPMCs. Moreover, F. fructus had no cytotoxic effects on cell viability and had inhibitory effects on TNF-α secretion from HMC-1. These results suggest that F. fructus is a potential herb medicine for treatment of inflammatory diseases through downmodulating mast cell activation.

Forsythia fructus mast cells oedema histamine tumor necrosis factor-α 

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Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Mi-Sun Kim
    • 1
    • 2
  • Ho-Jeong Na
    • 1
    • 2
  • Seung-Woo Han
    • 1
  • Jong-Sik Jin
    • 1
  • Un-Yong Song
    • 3
  • Eon-Jeong Lee
    • 3
  • Bong-Keun Song
    • 3
  • Seung-Heon Hong
    • 1
  • Hyung-Min Kim
    • 2
  1. 1.Department of Oriental Pharmacy, College of PharmacyWonkwang UniversityIksan, JeonbukSouth Korea.
  2. 2.Department of Pharmacology, College of Oriental MedicineKyung Hee UniversityDongdaemun-Gu, SeoulSouth Korea
  3. 3.College of Oriental MedicineWonkwang UniversityIksan, JeonbukSouth Korea

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