Journal of Pharmacokinetics and Biopharmaceutics

, Volume 26, Issue 1, pp 125–130 | Cite as

On Continuity of Integration Methods for AUC. A Note

  • Wojciech Jawień


A lack of monotonicity and discontinuity of some integration methods for AUC, as a function of measured concentration, is demonstrated. Hybrid methods consisting of either parabolas-through-the-origin or the α-function method followed by the log-trapezoidal method were found to be discontinuous at the switching point. The stable piecewise third-order polynomial method appeared to be nonmonotonic as well as discontinuous.

area-under-the-curve model-independent pharmacokinetics integration algorithms 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Wojciech Jawień
    • 1
  1. 1.Collegium Medicum of Jagiellonian University, ulKrakówPoland

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