Journal of Autism and Developmental Disorders

, Volume 33, Issue 2, pp 209–215 | Cite as

Brief Report: Cognitive Correlates of Enlarged Head Circumference in Children with Autism

  • Curtis K. Deutsch
  • Robert M. JosephEmail author


This study examined the frequency and cognitive correlates of enlarged head circumference in a sample of 63 children with autism between the ages of 4 and 14. Consistent with prior evidence, macrocephaly occurred at a significantly higher frequency than in a normal reference sample. Head circumference was not associated with language or executive functioning, nor was it related to verbal or nonverbal IQ. Head circumference was, however, correlated with discrepancies between verbal and nonverbal IQ scores, independent of absolute level of verbal ability. Children with discrepantly high nonverbal abilities had a mean standardized head circumference that was more than 1 SD greater than in the reference sample, and that was significantly greater than in autistic children with a relative verbal advantage or no discrepancy in cognitive abilities, for whom mean head circumference was within normal limits. This convergence of physical and cognitive features suggests a possible etiologically significant subtype of autism.

Autism head circumference IQ macrocephaly 


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  1. American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, D.C: Author.Google Scholar
  2. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.PubMedGoogle Scholar
  3. Bailey, A., Phillips, W., & Rutter, M. (1996). Autism: Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. Journal of Child Psychology and Psychiatry, 37, 89–126.PubMedGoogle Scholar
  4. Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.Google Scholar
  5. Brown, R. (1973). A first language. Cambridge, MA: Harvard University Press.Google Scholar
  6. Cohen, I. L. (1994). An artificial neural network analogue of learning in autism. Biological Psychiatry, 36, 5–20.PubMedGoogle Scholar
  7. Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., Lincoln, A. J., Pizzo, S., Schreibman, L, Haas, R. H., Akshoomoff, N. A., & Courchesne, R. Y. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology, 57, 245–254.PubMedGoogle Scholar
  8. Davidovitch, M., Patterson, B., & Gartside, P. (1996). Head circumference measurements in children with autism. Journal of Child Neurology, 11, 389–393.PubMedGoogle Scholar
  9. Deutsch, C. K., & Farkas, L. G. (1994). Quantitative methods of dysmorphology diagnosis. In L. G. Farkas (Ed.), Anthropometry of the head and face (2nd ed., pp. 151–158). New York: Raven.Google Scholar
  10. Deutsch, C. K., Folstein, S. E., Gordon-Vaughn, K., Tager-Flusberg, H., Schmid, C., Martino, B., & Sherman, D. (in press). Macrocephaly and cephalic disproportion in autistic probands and their first-degree relatives. American Journal of Medical Genetics.Google Scholar
  11. Deutsch, C., Hodge, S., Tager-Flusberg, H., Folstein, S., Steele, S., Laurer, E., Harris, G., Herbert, M., Reading, S., & Sherman, J. (2001, November). Macrocephaly and brachycephaly in autism: Correspondence of brain and cranial size/shape. Paper presented at the First International Meeting for Autism Research, San Diego, CA.Google Scholar
  12. Diamond, A., Prevor, M. B., Callender, G., & Druin, D. P. (1997). Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monographs of the Society for Research in Child Development (Vol. 62). Chicago: The University of Chicago Press.Google Scholar
  13. Dunn, L. M., & Dunn, L. M. (1997). Peabody Picture Vocabulary Test. Third Edition. Circle Pines, MN: American Guidance Service.Google Scholar
  14. Elliott, C. D. (1990). Differential ability scales: Introductory and technical handbook. New York: The Psychological Corporation.Google Scholar
  15. Farkas, L. G. (1994). Anthropometry of the head and face (2nd ed.), New York: Raven.Google Scholar
  16. Fidler, D., Bailey, J., & Smalley, S. (2000). Macrocephaly in autism and other pervasive developmental disorders. Developmental Medicine and Child Neurology, 42, 737–740.PubMedGoogle Scholar
  17. Folstein, S. E., & Piven, J. (1991). Etiology of autism: Genetic influences. Pediatrics, 87, 67–73.Google Scholar
  18. Fombonne, E., Rogé, B., Claverie, J., Courty, S., & Frémolle, J. (1999). Microcephaly and macrocephaly in autism. Journal of Autism and Developmental Disorders, 29, 113–119.PubMedGoogle Scholar
  19. Frith, U. (1989). Autism: Explaining the enigma. Oxford: Blackwell.Google Scholar
  20. Gerstadt, C., Hong, Y., & Diamond, A. (1994). The relationship between cognition and action: Performance of 3–7 year old children on a Stroop-like day-night test. Cognition, 53, 129–153.PubMedGoogle Scholar
  21. Happé, F. G. E. (1994). Wechsler IQ profile and theory of mind in autism: A research note. Journal of Child Psychology and Psychiatry, 35, 1461–1471.PubMedGoogle Scholar
  22. Happé, F. (1999). Autism: Cognitive deficit or cognitive style? Trends in Cognitive Sciences, 3, 216–222.PubMedGoogle Scholar
  23. Joseph, R. M., Tager-Flusberg, H., & Lord, C. (2002). Cognitive profiles and social-communicative functioning in children with autism. Journal of Child Psychology and Psychiatry, 43, 807–821.PubMedGoogle Scholar
  24. Korkman, M., Kirk, U., & Kemp, S. (1998). NEPSY: A developmental neuropsychological assessment. San Antonio, TX: The psychological Corporation.Google Scholar
  25. Lainhart, J. E., Piven, J., Wzorek, M., Landa, R., Santangelo, S. L., Coon, H., & Folstein, S. E. (1997). Macrocephaly in children and adults with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 282–290.PubMedGoogle Scholar
  26. Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989). Autism diagnostic interview: A standardized investigator-based instrument. Journal of Autism and Developmental Disorders, 19, 185–193.PubMedGoogle Scholar
  27. Lincoln, A., Courchesne, E., Allen, M., Hanson, E., & Ene, M. (1998). Neurobiology of Asperger syndrome: Seven case studies and quantitative magnetic resonance imaging findings. In E. Schopler, G. Mesibov, & L. J. Kunce (Eds.), Asperger syndrome or high-functioning autism? (pp. 145–166). New York: Plenum.Google Scholar
  28. Lincoln, A. J., Courchesne, E., Kilman, B. A., Elmasian, R., & Allen, M. (1988). A study of intellectual abilities in highfunctioning people with autism. Journal of Autism and Developmental Disorders, 18, 505–523.PubMedGoogle Scholar
  29. Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism Diagnostic Observation Schedule-WPS (ADOS-WPS). Los Angeles, CA: Western Psychological Services.Google Scholar
  30. Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–668.PubMedGoogle Scholar
  31. Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Lenventhal, B. L., DiLavore, P. S., Pickles, A., & Rutter, M. (2000). The Autism Diagnostic Observation Schedule-Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedGoogle Scholar
  32. Piven, J., Arndt, S., Bailey, J., & Andreasen, N. (1996). Regional brain enlargement in autism: A magnetic resonance imaging study. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 530–536.PubMedGoogle Scholar
  33. Rutter, M. (2000). Genetic studies of autism: From the 1970s into the millenium. Journal of Abnormal Child Psychology, 28, 3–14.PubMedGoogle Scholar
  34. Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London, Series B: 298, 199–209.Google Scholar
  35. Stevenson, R. E., Schroer, R. J., Skinner, C., Fender, & D., Simensen, R. J. (1997). Autism and macrocephaly. Lancet, 349, 1744–1745.PubMedGoogle Scholar
  36. Tager-Flusberg, H., Calkins, S., Nolin, T., Baumberger, T., Anderson, M., & Chadwick-Dias, A. (1990). A longitudinal study of language acquisition in autistic and Down syndrome children. Journal of Autism and Developmental Disorders, 20, 1–21.PubMedGoogle Scholar
  37. Williams, K. T. (1997). Expressive Vocabulary Test. Circle Pines, MN: American Guidance Service.Google Scholar
  38. Woodhouse, W., Bailey, A., Rutter, M., Bolton, P., Baird, G., & Le Couteur, A. (1996). Head circumference in autism and other pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 37, 665–671.PubMedGoogle Scholar
  39. World Health Organization (1993). International classification of diseases (10th ed.). Geneva: World Health Organization.Google Scholar

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  1. 1.Eunice Kennedy Shriver CenterUniversity of Massachusetts Medical SchoolWorcester
  2. 2.Boston University School of MedicineBoston

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