Silicon Chemistry

, Volume 1, Issue 3, pp 215–222 | Cite as

Amino acid and peptide chemistry on silicones

  • Frank J. LaRonde
  • Michael A. Brook
  • Gang Hu
Article

Abstract

Poly(dimethylsiloxanes), di-terminated with amino acids, were synthesized by employing the Diels-Alder reaction of cyclopentadiene- or furan-terminated poly(dimethylsiloxanes) with functional dienophiles including N-maleoyl-protected phenylalanine. The amino acid could be chain extended using conventional solution peptide coupling with DCC, DMAP and N-hydroxysuccinimide to give a dipeptide-terminated silicone. The molecular weight of the silicone component of the telechelic system could be increased by acid-catalyzed redistribution with octamethylcyclotetrasiloxane (D4).

functional silicones amino acids peptides 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Frank J. LaRonde
    • 1
  • Michael A. Brook
    • 1
  • Gang Hu
    • 1
  1. 1.Department of ChemistryMcMaster UniversityHamiltonCanada

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