Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems

  • Ben Korman
  • Les S. Jennings


We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.

anesthetic techniques continuous infusion pharmacokinetics 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    B. Korman, L. S. Jennings, and J. R. A. Rigg. Rapid attainment of steady-state plasma drug concentrations within precise limits. J. Pharmacokin. Biopharm. 26:319-328 (1998).CrossRefGoogle Scholar
  2. 2.
    W. E. Boyce and R. C. DiPrima. Elementary Differential Equations and Boundary Value Problems, 6th ed., John Wiley, New York, 1997, pp. 658-661.Google Scholar
  3. 3.
    J. M. Bailey. A technique for approximately maintaining constant plasma levels of intravenous drugs. Anesthesiology 78:116-123 (1993).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Ben Korman
    • 1
  • Les S. Jennings
    • 2
  1. 1.Department of AnaesthesiaRoyal Perth HospitalPerth, W.AAustralia
  2. 2.Centre for Applied Dynamics and Optimization, Department of MathematicsUniversity of Western AustraliaNedlands, W.AAustralia

Personalised recommendations