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Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems

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Abstract

We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.

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REFERENCES

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Authors and Affiliations

  1. Department of Anaesthesia, Royal Perth Hospital, Perth, W.A, 6000, Australia

    Ben Korman

  2. Centre for Applied Dynamics and Optimization, Department of Mathematics, University of Western Australia, Stirling Highway, Nedlands, W.A, 6907, Australia

    Les S. Jennings

Authors
  1. Ben Korman
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  2. Les S. Jennings
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Korman, B., Jennings, L.S. Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems. J Pharmacokinet Pharmacodyn 27, 325–328 (1999). https://doi.org/10.1023/A:1020951230947

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  • DOI: https://doi.org/10.1023/A:1020951230947

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