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Rapid Attainment of Steady-State Plasma Drug Concentrations Within Precise Limits in Multicompartment Mammillary Systems

  • Ben Korman
  • Les S. Jennings
Article

Abstract

We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.

anesthetic techniques continuous infusion pharmacokinetics 

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REFERENCES

  1. 1.
    B. Korman, L. S. Jennings, and J. R. A. Rigg. Rapid attainment of steady-state plasma drug concentrations within precise limits. J. Pharmacokin. Biopharm. 26:319-328 (1998).CrossRefGoogle Scholar
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    W. E. Boyce and R. C. DiPrima. Elementary Differential Equations and Boundary Value Problems, 6th ed., John Wiley, New York, 1997, pp. 658-661.Google Scholar
  3. 3.
    J. M. Bailey. A technique for approximately maintaining constant plasma levels of intravenous drugs. Anesthesiology 78:116-123 (1993).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Ben Korman
    • 1
  • Les S. Jennings
    • 2
  1. 1.Department of AnaesthesiaRoyal Perth HospitalPerth, W.AAustralia
  2. 2.Centre for Applied Dynamics and Optimization, Department of MathematicsUniversity of Western AustraliaNedlands, W.AAustralia

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