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Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal

  • Júlia Singer
  • László Vereczkey
Article
  • 35 Downloads

Abstract

A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.

achieving steady state absorption elimination equal 

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REFERENCES

  1. 1.
    W. L. Chiou. Compartment-and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion. J. Phamacokin. Biopharm. 8:311-318 (1980).CrossRefGoogle Scholar
  2. 2.
    I. A. Nestorov. Accumulation profiles during quasi-uniform multiple dosing regimens. J. Pharmacokin. Biopharm. 21:479-485 (1993).CrossRefGoogle Scholar
  3. 3.
    W. L. Chiou. Rapid compartment-and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics. J. Pharm. Sci. 68:1546-1547 (1979).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Júlia Singer
    • 1
  • László Vereczkey
    • 2
  1. 1.Clinical Research and DevelopmentChinoin Pharmaceutical and Chemical Works Ltd.BudapestHungary
  2. 2.Chemical Research CenterInstitute of Chemistry, Hungarian Academy of SciencesBudapestHungary

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