Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal
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A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.
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- 3.W. L. Chiou. Rapid compartment-and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics. J. Pharm. Sci. 68:1546-1547 (1979).PubMedCrossRefGoogle Scholar