Journal of Pharmacokinetics and Biopharmaceutics

, Volume 26, Issue 6, pp 735–741 | Cite as

Note: Caution in Use of Empirical Equations for Pharmacodynamic Indirect Response Models

  • Wojciech Krzyzanski
  • William J. JuskoEmail author


An empirical equation was recently proposed and used to characterize inhibitory drug effects on production of an endogenous substance. The limitations of this empirical equation are described utilizing mathematical equations and simulations based on the exact differential equation for Indirect Response Model I. The latter is preferable for fitting data using indirect response models.


Empirical Equation Relative Maximum Error Indirect Response Model Exact Explicit Solution Indirect Pharmacodynamic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  1. 1.Department of Pharmaceutics, School of PharmacyState University of New York at BuffaloBuffalo

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