Skip to main content
SpringerLink
Log in

Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

Extended-release solid dispersions of nonsteroidal antiinflammatory drugs were prepared by using aqueous polymeric dispersions of Eudragit RS30D and Eudragit RL30D as the inert carriers. The effects of different polymer ratios of Eudragit RS30D and Eudragit RL30D, different particle sizes, and different combination of various formulations of solid dispersions on the in vitro release kinetics of drugs from the dosage forms were investigated. A computer curve-fitting process was developed to choose the optimum formulation of the solid dispersion with the desired drug release profile. This process might offer the advantages of efficiency and simplicity in the formulation development of extended-release solid dispersions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. K. Sekiguchi and N. Obi. Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that the ordinary sulfathiazole in man. Chem. Pharm. Bull. 9:866–872 (1961).

    Google Scholar 

  2. W. L. Chiou and S. Riegelman. Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci. 60:1281–1302 (1971).

    Google Scholar 

  3. A. Hasegawa, H. Nakagawa, and I. Sugimoto. Bioavailability and stability of nifedipine enteric coating agent solid dispersion. Chem. Pharm. Bull. 33:388–391 (1985).

    Google Scholar 

  4. M. P. Oth and A. J. Moes. Sustained release solid dispersions of indomethacin with Eudragit RS and RL. Int. J. Pharm. 55:157–164 (1989).

    Google Scholar 

  5. A. Hasegawa, H. Nakagawa, and I. Sugimoto. Solid dispersion obtained from nifedipine and enteric coating agent. I. Dissolution behavior. Yakugaku Zasshi 104:485–489 (1984).

    Google Scholar 

  6. N. A. El-Gindy, A. H. Karara, and M. M. Abd El-khalet. Coprecipitate as a potential technique affecting drug release. Sci. Pharm. 44:315–322 (1976).

    Google Scholar 

  7. N. A. El-Gindy, A. H. Karara, and M. M. Abd El-Khalet. Preparation of prolonged release codeine tablets using the solid dispersion technique. Sci. Pharm. 48:229–235 (1980).

    Google Scholar 

  8. K. S. Murthy, N. A. Enders, M. Mahjour, and M. B. Fawzi. A comparative evaluation of aqueous enteric polymers in capsule coatings. Pharm. Technol. 10(10):36–46 (1986).

    Google Scholar 

  9. S. S. Jambheker, P. J. Breen, and Y. Rojanasakul. Influence of formulation and other factors on the release of chlorpheniramine maleate from polymer coated beads. Drug Dev. Ind. Pharm. 13(15):2789–2810 (1987).

    Google Scholar 

  10. RS/1, Release 4.0, BBN Software Products Corporation. 10 Fawcett Street, Cambridge, MA 02238.

  11. T. Higuchi. Mechanism of sustained-action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52:1145–1149 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, Northeastern University, 114 Mugar Building, Boston, Massachusetts, 02115

    Chris Ho & George Chiaw-Chi Hwang

Authors
  1. Chris Ho
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Chiaw-Chi Hwang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ho, C., Hwang, G.CC. Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique. Pharm Res 9, 206–210 (1992). https://doi.org/10.1023/A:1018933306162

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018933306162

Search

Navigation