Abstract
Increased activity in the hepatic sympatheticnervous system may exacerbate salt and water retentionin patients with liver cirrhosis. The aim of this studywas to evaluate sodium and water homeostasis in rats with cirrhosis induced bydiethylnitrosamine and to investigate the influence ofhepatic denervation in this model. Animals wererandomized into three groups: diethylnitrosamine-treatedrats with (N = 13) and without (N = 8) hepaticdenervation and control rats (N = 8). Rats were fed anormal salt diet (0.23% sodium ad libitum). The 24-hrmeasurements for sodium balance, water balance, andcreatinine clearance were performed every two weeks for 12weeks after surgery. Diethylnitrosamine-inducedcirrhosis was confirmed histologically. The cumulativechange in sodium balance in the innervateddiethylnitrosamine-treated rat increased progressively and wassignificantly higher than the control during the lastfour weeks of the study. Meanwhile, rats with hepaticdenervation showed significantly smaller changes incumulative sodium balance at week 12 than those in theinnervated group. The cumulative changes in waterbalance in the innervated group were significantlygreater at weeks 10 and 12 than those of the denervatedand control group, which remained unchangedthroughout the study. Creatinine clearance in theinnervated group decreased at weeks 10 and 12 byapproximately 70% from baseline (P < 0.05); incontrast, it did not change significantly in the denervatedgroup and control group throughout the study. Theseresults demonstrated that hepatic denervationameliorates sodium and water retention as well asglomerular function in cirrhosis model in rats.
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Kawai, B., Tada, T., Kunihiro, N. et al. Hepatic Denervation Ameliorates Sodium and Water Retention in Experimental Cirrhosis in Rats. Dig Dis Sci 42, 2292–2298 (1997). https://doi.org/10.1023/A:1018822902732
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DOI: https://doi.org/10.1023/A:1018822902732