Skip to main content
SpringerLink
Log in

Analysis of charge rejection by an ionomeric plasma polymerized film for biomedical sensor applications

  • Published:
Journal of Applied Electrochemistry Aims and scope Submit manuscript

Abstract

A thin novel ionomeric plasma polymerized perfluoroallylphosphonic acid (PPPAPA) film has been developed to improve biomedical sensor ionic selectivity. PPPAPA films (average thickness 470nm) were deposited on gold wire electrodes. The ability of PPPAPA to reject a negative organic interferant, ascorbate, was compared with the transport of a positive organic ion, dopamine, using cyclic voltammetry (CV) and chronocoulometry. From analysis of CV data, PPPAPA film-coated gold electrodes showed a 50% reduction in current density response for ascorbate and a 5% reduction in response for dopamine compared with bare gold electrodes. Apparent analyte diffusion coefficients, calculated from chronocoulometry of PPPAPA film-coated electrodes, showed a 50% reduction for ascorbate transport compared with dopamine. The results demonstrate that PPPAPA films are ion-selective and may have potential application as a biomedical sensor coating.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Janata, `Principles of Chemical Sensors', Plenum Press, New York (1989).

    Google Scholar 

  2. J. B. Justice, `Voltammetry in the Neurosciences: Principles, Methods and Applications', Humana Press, Clifton, NJ (1988).

    Google Scholar 

  3. R. A. Adams, Anal. Chem. 48 (1976) 1126.

    Google Scholar 

  4. R. M. Wightman, L. J. May and A. C. Michael, ibid. 60 (1988) 769.

    Google Scholar 

  5. M. E. Rice, A. F. Oke, C. W. Bradberry and R. N. Adams, Brain Res. 349 (1985) 151.

    Google Scholar 

  6. I. Hu and T. Kuwana, Anal. Chem. 58 (1986) 3235.

    Google Scholar 

  7. G. Dryhurst, K. M. Kadish, F. Scheller and R. Renneberg, `Biological Electrochemistry', Academic Press, New York (1982).

    Google Scholar 

  8. E. Palmisano and P. G. Zambonin, Anal. Chem. 65 (1993) 2690.

    Google Scholar 

  9. R. M. Wightman, private communication, University of North Carolina at Chapel Hill (1995).

  10. P. H. Hutson and G. Curzon, Biochem. J. 211 (1983) 1.

    Google Scholar 

  11. F. G. Gonon, C. M. Fombarlet, M. J. Buda and J. F. Pujol, Anal. Chem. 53 (1981) 1386.

    Google Scholar 

  12. F. Malem and D. Mandler, ibid. 65 (1993) 37.

    Google Scholar 

  13. Q. Cheng and A. Brajter-Toth, ibid. 67 (1995) 2767.

    Google Scholar 

  14. F. Sun, D. W. Grainger, D. G. Castner and D. R. Leach-Scampavin, Macromolecules 27 (1994) 3053.

    Google Scholar 

  15. H.-S. Yim, C. E. Kibbey, S.-C. Ma, D. M. Kliza, D. Liu, S.-B. Park, C. E. Torre and M. E. Meyerhoff, Biosens. Bioelectron. 8 (1993) 1.

    Google Scholar 

  16. J. Janata, Anal. Chem. 6 (1992) 196R.

    Google Scholar 

  17. R. Vaidya and E. Wilkins, Biomed. Instrum. Technol. 27 (1993) 486.

    Google Scholar 

  18. E. W. Kristensen, W. G. Kuhr and R. M. Wightman, Anal. Chem. 59 (1987) 1752.

    Google Scholar 

  19. J. E. Baur, E. W. Kristensen, L. J. May, D. Wiedemann and R. M. Wightman. ibid. 60 (1988) 1268.

    Google Scholar 

  20. J. Zhou and E. Wang. Anal. Chim. Acta 249 (1991) 489.

    Google Scholar 

  21. M. G. Gargullo and A. C. Michael, Anal. Chem. 66 (1994) 2621.

    Google Scholar 

  22. P. S. Cahill and R. M. Wightman, ibid. 67 (1995) 2599.

    Google Scholar 

  23. J. B. Zimmerman and R. M. Wightman, ibid. 63 (1991) 24.

    Google Scholar 

  24. F. Moussy and D. J. Harrison, ibid. 66 (1994) 674.

    Google Scholar 

  25. K. Pihel, Q. D. Walker and R. M. Wightman. ibid. 68 (1996) 2084.

    Google Scholar 

  26. C. R. Martin, I. Rubinstein, and A. J. Bard. J. Am. Chem. Soc. 104 (1982) 4817.

    Google Scholar 

  27. Z. Fan and D. J. Harrison, Anal. Chem. 64 (1992) 1304.

    Google Scholar 

  28. D. J. Harrison, R. F. B. Turner and H. P. Baltes. ibid. 60 (1988) 2002.

    Google Scholar 

  29. K. Yasuda, Y. Uchimoto, Z. Ogumi and Z. Takehara, J. Electrochem. Soc. 141 (1994) 2350.

    Google Scholar 

  30. N. Inagaki, S. Tasaka, and Y. Horikawa, J. Polym. Sci. A, Polym. Chem. 27 (1989) 3495.

    Google Scholar 

  31. M. J. Danilich, D. F. Gervasio, and R. E. Marchant, J. Appl. Polym. Sci. Polym. Symp. (USA) 54 (1993) 93.

    Google Scholar 

  32. Z. Ogumi, Y. Uchimoto and Z. Takehara, J. Electrochem. Soc. 137 (1990) 3319.

    Google Scholar 

  33. C. J. Brumlik, A. Parthasarathy, W. Chen and C. R. Martin, ibid. 141 (1994) 2273.

    Google Scholar 

  34. M. J. Danilich, D. Gervasio, D. J. Burton, and R. E. Marchant, Macromolecules 28 (1995) 5567.

    Google Scholar 

  35. M. J. Danilich, `Functional Group Control in Radiofrequency Plasma Polymers with Biomedical Applications', Case Western Reserve University, Ph.D. thesis (1994).

  36. R. E. Marchant and I. Wang, `Implantation Biology' (edited by R. S. Greco), CRC Press, Boca Raton (1994).

    Google Scholar 

  37. W. Norde and J. Lyklema, `The Vroman Effect' (edited by C. H. Bamford), VSP, Utrecht (1992) p. 1.

    Google Scholar 

  38. J. A. Dean, `Lange's Handbook of Chemistry', McGraw-Hill, New York (1973).

    Google Scholar 

  39. S. H. Cadle and S. Bruckenstein, Electroanal. Chem. Interfac. Electrochem. 48 (1973) 325.

    Google Scholar 

  40. R. E. Marchant, D. Yu, and C. Khoo, J. Polym. Sci. Polym. Chem. 27 (1989) 881.

    Google Scholar 

  41. H. Yasuda, `Plasma Polymerization', Academic Press, Orlando (1985).

    Google Scholar 

  42. F. L. McCrackin, `A FORTRAN program for analysis of ellipsometer measurements', National Bureau of Standards, Technical Note 479 (1969).

  43. S. D. Johnson, J. M. Anderson, and R. E. Marchant, J. Biomed. Mater. Res. 26 (1992) 915.

    Google Scholar 

  44. S. D. Johnson, `The Characterization and Biocompatibility Assessment of Plasma Polymerized Thin Films', Case Western Reserve University, MS. thesis (1993).

  45. M. E. G. Lyons, `Electroactive Polymer Electrochemistry' (edited by M. E. G. Lyons) Plenum Press, New York (1994) p.122.

    Google Scholar 

  46. L. C. Feldman and J. W. Mayer `Fundamentals of Surface and Thin Film Analysis', New York, North-Holland (1986).

  47. M. J. Danilich, D. J. Burton and R. E. Marchant, Vibr. Spectrosc. 9 (1995) 229.

    Google Scholar 

  48. A. R. Hillman, `Electrochemical Science and Technology of Polymers-1' (edited by R. G. Linford), Elsevier Applied Science, London (1987).

    Google Scholar 

  49. P. S. Fedkiw, S. Song, S. Sharma and J.-H. Ye, J. Electrochem. Soc. 142 (1995) 1909.

    Google Scholar 

  50. A. J. Bard and L. R. Faulkner, `Electrochemical Methods', John Wiley & Sons, New York (1980).

    Google Scholar 

  51. Z. Gao, B. Chen and M. Zi, J. Chem. Soc., Chem. Commun. (1993) 675.

  52. G. Nagy, G. A. Gerhardt, A. F. Oke, M. E. Rice, R. N. Adams, R. B. Moore, M. N. Szentermag and C. R. Martin, J. Electroanal. Chem. 188 (1985) 85.

    Google Scholar 

  53. J. Israelachvili, `Intermolecular and Surface Forces', Academic Press Limited, San Diego (1992).

    Google Scholar 

  54. T. D. Gierke and W. Y. Hsu, `Perfluorinated Ionomer Membranes' (edited by A. Eisenberg and H. L. Yeager), ACS, Washington (1982) p. 283.

    Google Scholar 

  55. V. K. Datye, P. L. Taylor and A. J. Hopfinger, Macromolecules 17 (1984) 1704.

    Google Scholar 

  56. S. H. Cadle and S. Bruckenstein. Electroanal. Chem. Interfac. Electrochem. 48 (1973) 325.

    Google Scholar 

  57. G. Gerhardt and R. N. Adams, Anal. Chem. 54 (1982) 2518.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA

    R. C. TUCKER  & R. E. MARCHANT

  2. Department of Materials Science & Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA

    I. SONG  & J. H. PAYER

Authors
  1. R. C. TUCKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. SONG
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. H. PAYER
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. E. MARCHANT
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

TUCKER , R.C., SONG , I., PAYER , J.H. et al. Analysis of charge rejection by an ionomeric plasma polymerized film for biomedical sensor applications. Journal of Applied Electrochemistry 27, 1079–1087 (1997). https://doi.org/10.1023/A:1018442811360

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018442811360

Keywords

Search

Navigation