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Torp-Ziegler Cyclization in the Synthesis of 3-Amino-4-cyanopyrrole Derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Polyfunctional derivatives of 3-aminopyrrole have been synthesized from several substituted β-enamino nitriles using Torp-Ziegler cyclization. These compounds are starting materials for further conversions, particularly for the synthesis of pyrrolo[3,2-d]- and pyrrolo[3,4-d]pyrimidines.

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REFERENCES

  1. A. V. Kadushkin, T. V. Golovko, S. G. Kalistratov, A. S. Sokolova, V. A. Chernov, and V. G. Granik, Khim.-farm. Zh., 545 (1987).

  2. A. V. Kadushkin, T. V. Stezhko, N. P. Solov'eva, and V. G. Granik, Khim. Geterotsikl. Soedin., 1616 (1987).

  3. A. V. Kadushkin, I. N. Nesterova, T. V. Golovko, I. S. Nikolaeva, T. V. Pushkina, A. N. Fomina, A. S. Sokolova, V. A. Chernov, and V. G. Granik, Khim.-farm. Zh., No. 11, 15 (1994).

  4. M. V. Mezentseva, A. V. Kadushkin, L. M. Alekseeva, A. S. Sokolova, and V. G. Granik, Khim.-farm. Zh., No. 12, 19 (1991).

  5. K. Gewald and U. Hain, DDR Patent 112756; Chem. Abstr., 84, 164600 (1976).

    Google Scholar 

  6. K. Gewald, H. Schafer, and E. Schindler, DDR Patent 138976; Chem. Abstr., 93, 71547 (1980).

    Google Scholar 

  7. L. V. Ershov, S. S. Kiselev, and V. G. Granik, Khim. Geterotsikl. Soedin., 538 (1984).

  8. M. I. Evstratova, S. V. Zelentsov, A. V. Kadushkin, L. I. Budanova, E. F. Kuleshova, G. A. Bogdanova, and V. G. Granik, Khim.-farm. Zh., No. 2, 52 (1995).

  9. V. G. Granik, A. V. Kadushkin, and J. Liebscher, Adv. Heterocycl. Chem., 72, 79 (1998).

    Google Scholar 

  10. M. I. Lim and R. S. Klein, Tetrahedron Lett., 22, 25 (1981).

    Google Scholar 

  11. M. Charton, J. Org. Chem., 28, 3121 (1963).

    Google Scholar 

  12. V. G. Granik, Dissertation for Doctor of Chemical Sciences, Moscow (1978).

  13. A. V. Kadushkin, I. F. Faermark, G. Ya. Shvarts, and V. G. Granik, Khim.-farm. Zh., No. 11–12, 62 (1992).

  14. L. V. Ershov and V. G. Granik, Khim. Geterotsikl. Soedin., 646 (1985).

  15. W. J. Middleton, J. Org. Chem., 31, 3731 (1966).

    Google Scholar 

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Ryndina, S.A., Kadushkin, A.V., Solov'eva, N.P. et al. Torp-Ziegler Cyclization in the Synthesis of 3-Amino-4-cyanopyrrole Derivatives. Chemistry of Heterocyclic Compounds 36, 1409–1420 (2000). https://doi.org/10.1023/A:1017566212124

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  • DOI: https://doi.org/10.1023/A:1017566212124

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