Abstract
Syntheses are reported for a series of 2-alkylamino-6-phenyl-4-trifluoromethylpyridines. The reaction of 3-cyano-2-(hydroxyalkylamino)-6-phenyl-4-trifluoromethylpyridines with thionyl chloride gave the corresponding 2-(chloroalkylamino)pyridines, 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydro-imidazo[1,2-a]pyridines, and 9-cyano-6-phenyl-8-trifluoromethyl-2,3,4-trihydropyrido[1,2-a]-pyrimidines. X-ray diffraction structural analysis was used to study 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridine.
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REFERENCES
E. Yu. Gudriniece, M. Yu. Lidak, M. V. Yure, G. V. Vladyko, S. N. Nikolaev, E. I. Boreko, and P. G. Rytik, USSR Inventor's Certificate No. 1769 515; Byul. Izobr., No. 10 (1992).
E. Yu. Gudriniece, M. Y. Lidak, M. V. Yure, G. V. Vladyko, E. I. Boreko, and V. I. Botykov, USSR Inventor's Certificate No. 1704 417; Byul. Izobr., No. 1 (1992).
A. V. Guttsait, S. V. Belyakov, A. F. Mishnev, Ya. Ya. Breidelis, and E. Yu. Gudriniece, Khim. Geterotsikl. Soedin., 1233 (1987).
M. V. Yure, E. Yu. Gudriniece, M. V. Petrova, E. K. Rantsane, and E. B. Mazheika, Izv. Akad. Nauk LatvSSR, Ser. Khim., 439 (1990).
O. Bremer, Liebigs Ann. Chem., 521, 286 (1936).
L. Cossey, R. L. N. Harris, J. L. Hupatz, and J. N. Phillips, Austr. J. Chem., 29, 1039 (1976).
E. Suloeva, M. Yure, and E. Gudriniece, Khim. Geterotsikl. Soedin., 1299 (1999).
E. Suloeva, M. Yure, and E. Gudriniece, Khim. Geterotsikl. Soedin., 1011 (2000).
A. F. Mishnev and S. V. Belyakov, Kristallografiya, 33, 835 (1988).
P. Gluzinskii, Ya. Kraevskii, A. Kemme, and A. Kemme, in: Abstracts of the Second All-Union Conference on Precision Studies of Crystal Structure[in Russian], Riga (1990), p. 30.
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Suloeva, E., Yure, M., Gudriniece, E. et al. Synthesis of 5-Phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridines. Chemistry of Heterocyclic Compounds 37, 329–337 (2001). https://doi.org/10.1023/A:1017511217288
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DOI: https://doi.org/10.1023/A:1017511217288