Abstract
Working conditions were found for determining the novocaine salt of benzylpenicillin antibiotic as its 4,6-dinitrobenzofuroxan derivative by flow-injection analysis with spectrophotometric detection (λ = 510 nm). The best results were obtained for flows of methanol (ethanol) and water with a volume ratio of 30 : 70. The calibration range of the pharmaceutical is 0.28–10 μg/mL with a throughput capacity of 30 samples/h. The limit of detection (3σ, n= 4) is 0.14 μg/mL. Amino acids and components of penicillin-containing pharmaceuticals did not interfere with the determination. Procedures for determining benzylpenicillin novocaine salt in medicinal formulations containing benzylpenicillin N,N"-dibenzylethylenediamine, potassium, and sodium salts and some other
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Evgen'ev, M.I., Garmonov, S.Y. & Shakirova, L.S. Flow-Injection Determination of Benzylpenicillin Novocaine Salt in Penicillin Preparations with Spectrophotometric Detection. Journal of Analytical Chemistry 56, 572–576 (2001). https://doi.org/10.1023/A:1016645114098
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DOI: https://doi.org/10.1023/A:1016645114098