Pharmaceutical Research

, Volume 3, Issue 3, pp 170–172 | Cite as

Fungal Metabolism of 4-Methylprimaquine

  • Alice M. Clark
  • James D. McChesney
  • Charles D. Hufford

Abstract

4-Methylprimaquine (4-MPQ), an 8-aminoquinoline antimalarial drug, was subjected to microbial metabolism studies in an effort to isolate, identify, and predict the probable mammalian metabolite(s). Preliminary screening with a number of strains of Aspergillus indicated that several species were capable of metabolizing 4-MPQ to one major metabolite based on thin-layer chromatographic analysis. Preparative scale conversion of 4-MPQ using whole-cell suspensions of Aspergillus ochraceus afforded one major metabolite (4-MPQ-I). Based on spectroscopic and chemical evidence, the structure of the metabolite is proposed as 6-methoxy-8-(3-carboxyl-l-methylpropylamino)-lepidine.

4-methylprimaquine, fungal metabolism 8-aminoquinoline, metabolism Aspergillus ochraceus, 4-methylprimaquine metabolism 

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Alice M. Clark
    • 1
  • James D. McChesney
    • 1
  • Charles D. Hufford
    • 1
  1. 1.Department of Pharmacognosy, School of PharmacyThe University of MississippiUniversity

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