Russian Chemical Bulletin

, Volume 51, Issue 5, pp 854–859 | Cite as

Application of the Thorpe—Ziegler reaction for the synthesis of functionalized thiophenes, thienopyrimidines, and thienotriazines

  • S. A. Ryndina
  • A. V. Kadushkin
  • N. P. Solov"eva
  • V. G. Granik

Abstract

Approaches to the synthesis of 3-aminothiophene-2,4-dicarboxylic acid derivatives and to their conversions into thieno[3,4-d]pyrimidines, thieno[3,4-d]-1,2,3-triazines, and thieno[3,2-d]pyrimidines are developed.

enamines the Thorpe—Ziegler cyclization thiophenes pyrimidines 1,2,3-triazines 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • S. A. Ryndina
    • 1
  • A. V. Kadushkin
    • 1
  • N. P. Solov"eva
    • 2
  • V. G. Granik
    • 1
  1. 1.State Scientific Center of the Russian Federation “Organic Intermediate Products and Dyes Institute” (NIOPIK)MoscowRussian Federation
  2. 2.Center of Drug ChemistryAll-Russian Research Chemical Pharmaceutical InstituteMoscowRussian Federation

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