Bulletin of Experimental Biology and Medicine

, Volume 133, Issue 3, pp 290–292 | Cite as

Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats

  • V. Kh. Khavinson
  • V. V. Malinin
  • N. M. Timofeeva
  • V. V. Egorova
  • A. A. Nikitina
Article

Abstract

Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract. The most pronounced activation of enzymes was observed in 11-month-old animals. This effect diminished the differences in enzyme activities between young and old rats (compared to untreated animals). Our results indicate that Epithalon modulates activity of gastrointestinal enzymes during aging.

Epithalon peptides digestive enzymes gastrointestinal tract aging 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    A. A. Boldyrev, Carnosine: Biological Importance and Use in Clinical Practice [in Russian], Moscow (1998).Google Scholar
  2. 2.
    L. N. Valenkevich, Human Digestive System during Aging [in Russian], Leningrad (1984).Google Scholar
  3. 3.
    L. N. Valenkevich and A. M. Ugolev, Biology of Aging [in Russian], Leningrad (1982), pp. 343–369.Google Scholar
  4. 4.
    O. A. Gomazkov, Functional Biochemistry of Regulatory Peptides [in Russian], Moscow (1992).Google Scholar
  5. 5.
    B. I. Kuznik, V. G. Morozov, and V. Kh. Khavinson, Cytomedines: Experience of 25–Year Experimental and Clinical Studies [in Russian], St. Petersburg (1998).Google Scholar
  6. 6.
    Membrane Hydrolysis and Transport. New Data and Hypotheses [in Russian], Ed. A. M. Ugolev, Leningrad (1986).Google Scholar
  7. 7.
    V. G. Morozov, V. Kh. Khavinson, and V. V. Malinin, Peptide Thymomimetics [in Russian], St. Petersburg (2000).Google Scholar
  8. 8.
    A. M. Ugolev, V. V. Egorova, N. N. Iezuitova, et al., Fiziol. Zh., 78, 29–37 (1992).Google Scholar
  9. 9.
    V. Kh. Khavinson and V. G. Morozov, Peptides from the Pineal Gland and Thymus in the Regulation of Aging [in Russian], St. Petersburg (2001).Google Scholar
  10. 10.
    V. Kh. Khavinson, V. V. Popuchiev, I. M. Kvetnoi, et al., Byull. Eksp. Biol. Med., 130, No. 12, 651–653 (2000).Google Scholar
  11. 11.
    V. Kh. Khavinson, N. M. Timofeeva, V. V. Malinin, et al., Ibid., 131, No. 6, 690–693 (2001).Google Scholar
  12. 12.
    V. N. Anisimov, A. S. Loktionov, V. Kh. Khavinson, and V. G. Morozov, Mech. Ageing Dev., 49, 245–257 (1989).Google Scholar
  13. 13.
    V. K. Ghanta, N. S. Hiramoto, S.-J. Soong, and R. N. Hiramoto, Ann. N. Y. Acad. Sci., 621, 239–255 (1991).Google Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • V. Kh. Khavinson
    • 1
    • 2
  • V. V. Malinin
    • 1
    • 2
  • N. M. Timofeeva
    • 1
    • 2
  • V. V. Egorova
    • 1
    • 2
  • A. A. Nikitina
    • 1
    • 2
  1. 1.St. Petersburg Institute of Bioregulation and GerontologyNorthwestern Division of the Russian Academy of Medical SciencesRussia
  2. 2.I. P. Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

Personalised recommendations