This is a preview of subscription content, log in via an institution to check access.
REFERENCES
A. J. Lin, N. L. Slack, A. Ahmad, I. Koltover, C. X. George, C. E. Samuel, and C. R. Safinya. Structure and structure-function studies of lipid/plasmid DNA complexes. J. Drug Target 8:13-27 (2000).
N. Smyth Templeton, D. D. Lasic, P. M. Frederik, H. H. Strey, D. D. Roberts, and G. N. Pavlakis. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nat. Biotech. 15:647-652 (1997).
P. Tarn, M. Monck, D. Lee, O. Ludkovski, E. C. Leng, K. Clow, P. Scherrer, R. W. Graham, and P. R. Cullis. Stabilized plasmid-lipid particles for systemic gene therapy. Gene. Ther. 7:1867-1874 (2000).
K. Hong, W. Zheng, A. Baker, and D. Papahadjopoulos. Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery. FEES Lett. 400:233-237 (1997).
S. Li, W. C. Tseng, D. Beer Stolz, S. P. Wu, S. C. Watkins, and L. Huang. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection. Gene. Ther. 6:585-594 (1999).
M. Ogris, S. Brunner, S. Schuller, R. Kircheis, and E. Wagner. Pegylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene. Ther. 6:595-605 (1999).
T. Blessing, J. S. Remy, and J. P. Behr. Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc. Natl. Acad. Sci. USA 95:1427-1431 (1998).
M. A. Monck, A. Mory, D. Lee, P. Tarn, J. J. Wheeler, P. R. Cullis, and P. Scherrer. Stabilized plasmid-lipid particles: pharmacokinetics and plasmid delivery to distal tumors following intravenous injection. J. Drug Target 7:439-452 (2000).
F. Liu, J. Yang, L. Huang, and D. Liu. Effect of non-ionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transfer. Pharm. Res. 13:1642-1646 (1996).
S. W. Yi, T. Y. Yune, T. W. Kim, H. Chung, Y. W. Choi, I. C. Kwon, E. B. Lee, and S. Y. Jeong. A cationic lipid emulsion/DNA complex as a physically stable and serum-resistant gene delivery system. Pharm. Res. 17:314-320 (2000).
T. Hara, Y. Tan, and L. Huang. In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector. Proc. Natl. Acad. Sci. USA 94:14547-14552 (1997).
J. J. Wheeler, K. F. Wong, S. M. Ansell, D. Masin, and M. B. Bally. Polyethylene glycol modified phospholipids stabilize emulsions prepared from triacylglycerol. J. Pharm. Sci. 83:1558-1564 (1994).
I. Koltover, T. Salditt, and C. R. Safinya. Phase diagram, stability, and overcharging of lamellar cationic lipid-DNA self-assembled complexes. Biophys. J. 77:915-924 (1999).
I. Koltover, T. Salditt, J. O. Radler, and C. R. Safinya. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science 281:78-80 (1998).
T. Sakaeda and K. Hirano. Effect of composition on biological fate of oil particles after intravenous injection of O/W lipid emulsions. J. Drug Target 6:273-284 (1998).
M. Nishikawa, Y. Takakura, and M. Hashida. Biofate of fat emulsions. In S. Benita (ed.), Submicron emulsions in drug targeting and delivery, Harwood Academic Publishers, Amsterdam, 1998 pp. 99-118.
B. B. Lundberg, B. C. Mortimer, and T. G. Redgrave. Submicron lipid emulsions containing amphipathic polyethylene glycol for use as drug-carriers with prolonged circulation time. Int. J. Pharm. 134:119-127 (1996).
F. Liu and D. Liu. Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs. Pharm. Res. 12:1060-1064 (1995).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chesnoy, S., Durand, D., Doucet, J. et al. Improved DNA/Emulsion Complex Stabilized by poly(ethylene glycol) Conjugated Phospholipid. Pharm Res 18, 1480–1484 (2001). https://doi.org/10.1023/A:1012221310136
Issue Date:
DOI: https://doi.org/10.1023/A:1012221310136