Skip to main content
SpringerLink
Log in

Annexins

  • Published:
Biometals Aims and scope Submit manuscript

Abstract

The annexins are a family of proteins that bind anionic phospholipid surfaces in a Ca 2+ -dependent manner (general reviews include Raynal & Pollard 1994, Swairjo & Seaton 1994, Seaton 1996, Mollenhauer, 1997). Due to this functional property, individual annexins have been discovered independently by numerous labo-ratories with diverse experimental goals. Ca 2+ characteristically causes the annexins to shift from a soluble to membrane associated state. This shift is believed to be the mechanism that underlies annexin cellular function.© Kluwer Academic Publishers

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ahluwalia A, Buckingham JC, Croxtall JD, Flower RJ, Goulding NJ, Perretti M. 1996 The biology of annexin I. Seaton BA, ed. Annexins: Molecular Structure to Cellular Function. R.G. Landes Co., Austin Texas. pp 161–199

    Google Scholar 

  • Andree HAM, Stuart MCA, Hermens WTh, et al. 1992 Clustering of lipid-bound annexin V may explain its anticoagulant effect. J Biol Chem 267, 17907–17912

    Google Scholar 

  • Benz J, Bergner A, Hofmann A et al. 1996 The structure of recombinant annexin VI in crystals and membrane-bound. J Mol Biol 260, 638–643

    Google Scholar 

  • Berendes R, Voges D, Demange P et al. 1993 Structure-function analysis of the ion channel selectivity filter in human annexin V. Science 262, 427–430

    Google Scholar 

  • Campos B, Mo YD, Mealy TR. et al. 1998 Mutational and crystallographic analyses of interfacial residues in annexin V suggest direct interactions with phospholipid membrane components. Biochemistry 37, 8004–8010

    Google Scholar 

  • Chollet P, Malecaze F, Hullin F, et al. 1992 Inhibition of intraocular fibrin formation with annexin V. Br J Ophthalmol 76, 450–452

    Google Scholar 

  • Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA. 1992 Annexin V forms a calcium-dependent trimeric unit structure on phospholipid vesicles. FEBS Lett 314, 159–162

    Google Scholar 

  • Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA. 1993 Rat annexin V crystal structure: Ca2+-induced conformational changes. Science 261, 1321–1324

    Google Scholar 

  • Demange P, Voges D, Benz J et al. 1994 Annexin V: the key to understanding ion selectivity and voltage regulation? Trends Biochem. Sci. 19, 272–276

    Google Scholar 

  • De Meyer S, Gong ZJ, Suwandhi W, et al. 1997 Organ and species specificity of hepatitis B virus (HBV) infection: a review of literature with a special reference to preferential attachment of HBV to human hepatocytes. J Viral Hepat 4, 145–153

    Google Scholar 

  • Dubois T, Oudinet JP, Mira JP, Russo-Marie F. 1996 Annexins and protein kinases C. Biochim Biophys Acta 1313, 290–294

    Google Scholar 

  • Dubois T, Mira JP, Feliers D. 1998 Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration. Biochem J 330, 1277–1282

    Google Scholar 

  • Gerke V, Moss SE. 1997 Annexins and membrane dynamics. Biochim Biophys Acta 1357, 129–154

    Google Scholar 

  • Gunteski-Hamblin AM, Song G, Walsh RA et al. 1996 Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice. Am J Physiol 270, H1091–H1100

    Google Scholar 

  • Hajjar KA, Mauri L, Jacovina AT et al. 1998 Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J Biol Chem 273, 9987–9993

    Google Scholar 

  • Harder T, Gerke V. 1993 The subcellular distribution of early endosomes is affected by the annexin IIp11(2) complex. J Cell Biol 123, 1119–1132

    Google Scholar 

  • Hofmann A, Escherich A, Lewit-Bentley et al. 1998 Interactions of benzodiazepine derivatives with annexins. J Biol Chem 273, 2885–2894

    Google Scholar 

  • Jost M, Gerke V. 1996 Mapping of a regulatory important site for protein kinase C phosphorylation in the Nterminal domain of annexin II. Biochim Biophys Acta 1313, 283–289

    Google Scholar 

  • Kaetzel MA, Dedman JR. 1995 Annexins: Novel Ca2+-dependent regulators of membrane function. News in Physiological Sciences 10, 171–176

    Google Scholar 

  • Kaetzel MA, Chan HC, Dubinsky WP, Dedman JR, Nelson DJ. 1994 A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance. J Biol Chem 269, 5297–5302

    Google Scholar 

  • Kaneko N, Ago Hm Matsuda R, Inagaki E, Miyano M. 1997 Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. J Mol Biol 274, 16–20

    Google Scholar 

  • Kawasaki H, Avila-Sakar A, Creutz CE, Kretsinger RH. 1996 The crystal structure of annexin VI indicates relative rotation of the two lobes upon membrane binding. Biochim Biophys Acta 1313, 277–282

    Google Scholar 

  • Kirsch T, Nah HD, Demuth DR et al. 1997 Annexin V-mediated calcium flux across membranes is dependent on the lipid composition: implication for cartilage mineralization. Biochemistry 36, 3359–3367

    Google Scholar 

  • Lamberto O, Gerke V, Bader MF, Porte F, Brisson A. 1997 Structural analysis of junctions formed between lipid membranes and several annexins by cryo-electron microscopy. J Mol Biol 272, 42–55

    Google Scholar 

  • Luecke H, Chang BT, Maillard WS, Schlaepfer DD, Haigler HT. 1995 Crystal structure of the annexin XII hexamer and implications for bilayer insertion. Nature 378, 512–515

    Google Scholar 

  • Meers P, Mealy T. 1993 Relationship between annexin V tryptophan exposure, calcium, and phospholipid binding. Biochemistry 32, 5411–5418

    Google Scholar 

  • Mollenhauer J, ed. 1997. Annexins. Cell Mol Life Sci 53, 506–556.

  • Morgan RO, Fernández MP. 1997 Annexin gene structures and molecular evolutionary genetics. Cell Mol Life Sci 53, 508–515

    Google Scholar 

  • Naciff JM, Behbehani MM, Kaetzel MA, Dedman JR. 1996b Annexin VI modulates Ca2+ and K+ conductances of spinal cord and dorsal root ganglion neurons. Am J Physiol 271, C2004–C2015

    Google Scholar 

  • Naciff JM, Kaetzel MA, Behbehani MM, Dedman JR. 1996a Differential expression of annexins I-VI in the rat dorsal root ganglia and spinal cord. J Comp Neurol 368, 356–370

    Google Scholar 

  • Nevid NJ, Horseman ND. 1996 Annexin gene structure. Seaton BA, ed. Annexins: Molecular Structure to Cellular Function. R.G. Landes Co., Austin Texas. pp 1–14

    Google Scholar 

  • Olofsson A, Mallouh V, Brisson A. 1995 A 8Å projection structure of membrane bound human annexin V. J Struct Biol 113, 199–205

    Google Scholar 

  • Pietropaolo RL, Compton T. 1997 Direct interaction between human cytomegalovirus glycoprotein B and cellular annexin II. J Virol 71, 9803–9807

    Google Scholar 

  • Pigault C, Follenius-Wund A, Schmutz M, Freyssinet JM, Brisson A. 1994 Formation of two dimensional arrays of annexin V on phosphatidylserine-containing endosomes. J Mol Biol 236, 199–208

    Google Scholar 

  • Raynal P, Pollard HB. 1994 Annexins: a novel family of calcium-and membrane-binding proteins in search of a function. Biochim Biophys Acta 1197, 63–93

    Google Scholar 

  • Reutelingsperger CPM, van Heerde WL. 1997 Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis. Cell Mol Life Sci 53, 527–532

    Google Scholar 

  • Römisch J, Seiffge D, Reiner G et al. 1991 In vivo antithrombotic potency of placenta protein 4 (annexin V). Thromb Res 61, 93–104

    Google Scholar 

  • Rothhut B. 1997 Participation of annexins in protein phosphorylation. Cell Mol Life Sci 53, 522–526

    Google Scholar 

  • Seaton BA, ed. 1996 Annexins: molecular structure to cellular function. R.G. Landes Company, Austin TX

  • Siever DA, Erickson HP. 1997 Extracellular annexin II. Int J Biochem Cell Biol 29, 1219–1223

    Google Scholar 

  • Sopkova J, Renouard M, Lewit-Bentley A. 1993 The crystal structure of a new high-calcium form of annexin V. J Mol Biol 234, 816–825

    Google Scholar 

  • Swairjo MA, Seaton BA. 1994 Annexin structure and membrane interactions: a molecular perspective. Annu Rev Biophys Biomolec Struct 23, 193–213

    Google Scholar 

  • Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA. 1995 Ca2+ bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat Struct Biol 2, 968–974

    Google Scholar 

  • Tait JF, Gibson D, Fujikawa K. 1989 Phospholipid binding properties of human placental anticoagulant protein-I, a member of the lipocortin family. J. Biol. Chem. 264, 7944–7949

    Google Scholar 

  • Tait JF, Cerqueira MD, Dewhurst TA et al. 1994 Evaluation of annexin V as a platelet-directed thrombus targeting agent. Thrombosis Res. 75, 491–501

    Google Scholar 

  • Tait JF, Engelhardt S, Smith C et al. 1995 Prourokinaseannexin V chimeras: construction, expression, and characterization of recombinant proteins. J Biol Chem 270, 21594–21599

    Google Scholar 

  • Upton AL, Edwards HC, Moss SE. 1996 Ca2+-independent functions of annexins. Seaton BA, ed. Annexins: Molecular Structure to Cellular Function. R.G. Landes Co., Austin Texas. pp 121–132

    Google Scholar 

  • van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. 1998 Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31, 1–9

    Google Scholar 

  • VanRyn-McKena J, Merk H, Muller TH et al. 1993. The effects of heparin and annexin V on fibrin accretion after injury in the jugular veins of rabbits. Thromb Haemost 69, 227–230

    Google Scholar 

  • Voges D, Berendes R, Burger A et al. 1994 Three-dimensional structure of membrane-bound annexin V. A correlative electron microscopy-X-ray crystallography study. J Mol Biol 238, 199–213

    Google Scholar 

  • Voges D, Berendes R, Demange P et al. 1995 Structure and function of the ion channel model system annexin V. Adv Enzymol Relat Areas Mol Biol 71, 209–239

    Google Scholar 

  • von der Mark K, Mollenhauer J. 1997 Annexin V interactions with collagen. Cell Mol Life Sci 53, 539–545

    Google Scholar 

  • Waisman DM. 1995 Annexin II tetramer: structure and function. Mol Cell Biochem 149–150, 301–322

    Google Scholar 

  • Yokoyama T, Kelly AB, Hanson SR et al. 1994 Anti-thrombotic effects of annexin V in nonhuman primates. Blood 84, 245a

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Structural Biology Group (B.A.S.), Boston University School of Medicine, 80 East Concord Street, Boston, MA, 02118, USA

    Barbara A Seaton & John R Dedman

Authors
  1. Barbara A Seaton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John R Dedman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seaton, B.A., Dedman, J.R. Annexins. Biometals 11, 399–404 (1998). https://doi.org/10.1023/A:1009205925714

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1009205925714

Search

Navigation