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Genetic Determinants of Predisposition to Bronchial Asthma

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Abstract

The ratio between the normal (+) and null (0) alleles of the genes encoding glutatione S-transferases M1 (GSTM1) and T1 (GSTT1) were studied in normal individuals from northwestern Russia (control group) and in patients with bronchial asthma (BA). The frequency of the GSTM1 0/0 genotype in the population sample was statistically significantly lower (37.8%) than in the BA patients (82.1%; χ2 = 16.8;P< 0.001; Wχ2 = 15.7; α = 0.01). For the GSTT1 gene, similar data were obtained. The frequency of the GSTT1 0/0 genotype in healthy donors was statistically significantly higher (16.3%) than in the BA patients (73.7%; χ2 = 28.5;P < 0.001; Wχ2 = 23.22; α = 0.01). A significant preponderance of the compound homozygotes for the GSTM1 and GSTT1 null alleles among the BA patients was observed. The frequency of the GSTM1 0/0, GSTT10/0 individuals among the patients was 57.9%, while it was only 4.7% among the controls (χ2 = 27.4; P < 0.001).

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Authors and Affiliations

  1. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, 199034, Russia

    T. E. Ivaschenko & O. G. Sideleva

  2. Pavlov Institute of Pulmonology, St. Petersburg Medical Academy, St. Petersburg, 197089, Russia

    M. A. Petrova & T. E. Gembitskaya

  3. St. Olga's Children's Hospital, St. Petersburg, 197100, Russia

    A. V. Orlov & V. S. Baranov

Authors
  1. T. E. Ivaschenko
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  2. O. G. Sideleva
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  3. M. A. Petrova
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  4. T. E. Gembitskaya
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  5. A. V. Orlov
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  6. V. S. Baranov
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Ivaschenko, T.E., Sideleva, O.G., Petrova, M.A. et al. Genetic Determinants of Predisposition to Bronchial Asthma. Russian Journal of Genetics 37, 94–97 (2001). https://doi.org/10.1023/A:1009030911764

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