Virus Genes

, Volume 22, Issue 1, pp 93–101

The Hamster Polyomavirus—a Brief Review of Recent Knowledge*

  • Siegfried Scherneck
  • Rainer Ulrich
  • Jean Feunteun
Article

Abstract

The hamster polyomavirus (HaPV) was first described in 1967 as a virus associated with skin epithelioma of the Syrian hamster. The tumors appear spontaneously in a hamster colony bred in Berlin-Buch (HaB). Virus particles isolated from skin epitheliomas cause lymphoma and leukemia when injected into newborn hamsters from a distinct colony bred in Potsdam, Germany (HaP). The viral genome has been totally sequenced and the overall genetic organization establishes HaPV as a member of the polyomaviruses. HaPV is a second example of an middle T (MT) antigen encoding polyomavirus and nucleotide sequence homologies designates the mouse polyomavirus (Py) as the closest relative.

Lymphomas induced by HaPV in HaP hamsters do not contain virus particles but instead accumulate different amounts of nonrandomly deleted free and/or integrated viral genomes. Transgenic mice produced by microinjection of HaPV DNA into the pronucleus of fertilized eggs of Gat: NMRI mice developed both, epitheliomas and lymphomas. Both tumor types contain extrachromosomal DNA.

HaPV DNA was found to replicate in hamster lymphoid and fibroblast cell lines. Fully reproductive cycles could be detected only in GD36 lymphoblastic leukemia cells.

HaPV carries the full transforming properties of a polyomavirus in vitro. Immortalization of primary rat cells is essentially carried out by the HaPV large T (LT) antigen and coexpression of HaPV MT and HaPV small T (ST) antigen is required for full transformation of rat fibroblasts. The preferential binding of HaPV MT to c-Fyn, a Src family kinase, has been proposed as a mechanism leading to lymphoid malignancies.

Heterologous expression of HaPV-VP1 allowed the formation of virus like particles (VLPs) resembling HaPV particles. The high flexibility of HaPV-VP1 for insertion of foreign peptides offers a broad range of potential applications, especially in vaccine development.

polyomaviruses hamster polyomavirus Syrian hamster tumor virus antigens virus transformation Src family kinases virus-like particles 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Graffi A., Schramm T., Bender E., Bierwolf D., and Graffi I., Arch Geschwulstforsch 30, 227-283, 1967.Google Scholar
  2. 2.
    GraffI A., Schramm T., Graffi I., Bierwolf D., and Bender E., J Natl Cancer Inst 40, 867-873, 1968.Google Scholar
  3. 3.
    Graffi A., Bender E., Schramm T., Graffi I., and Bierwolf D., Comp Leukemia Res Bibl Haematol 36, 293-303, 1970.Google Scholar
  4. 4.
    Graffi I., Bierwolf D., Schramm T., Bender E., and Graffi A., Arch Geschwulstforsch 40, 191-236, 1972.Google Scholar
  5. 5.
    Heinecke H., Monatsberichte der Deutschen Akademie der Wissenschaften zu Berlin, 7, 52-56, 1965.Google Scholar
  6. 6.
    Coggin J.M., Jr., Hyde B.M., Heath L.S., Leinbach S.S., Fowler E., and Stadtmore L.S., J Natl Cancer Inst 75, 91-97, 1985.Google Scholar
  7. 7.
    Böttger M. and Scherneck S., Arch Geschwulstforsch 55, 225-233, 1985.Google Scholar
  8. 8.
    Böttger M., Bierwolf D., Wunderlich V., and Graffi A., Biochim Biophys Acta 232, 21-31, 1971.Google Scholar
  9. 9.
    Hassen S., Özel M., Jandrig B., Voronkova T., Jia W., Zocher R., Arnold W., Scherneck S., Krüger D.H., and Ulrich R., Virus Genes 18, 39-47, 1998.Google Scholar
  10. 10.
    Delmas V., Bastien C., Scherneck S., and Feunteun J., EMBO J 4, 1279-1286, 1985.Google Scholar
  11. 11.
    De la Roche Saint Andre C., Delmas V., Bastien C., Goutebrouze L., Scherneck S., and Feunteun J., in Villareal L.P., and Washington D.C. (eds.) Common-Mechanism of Transformation by Small DNA Tumor Viruses, American Society for Microbiology, Washington, pp. 225-238, 1989.Google Scholar
  12. 12.
    Zur Hausen H. and Gissmann L., Med Microbiol Immunol 167, 137-153, 1979.Google Scholar
  13. 13.
    Vogel F., Rhode K., Scherneck S., Bastien C., Delmas V., and Feunteun S., Virology 154, 335-343.Google Scholar
  14. 14.
    Ulrich R., Sommerfeld K., Schröder A., Prokoph H., Arnold W., Krüger D.H., and Scherneck S., Virus Genes 12, 265-274, 1996.Google Scholar
  15. 15.
    Sasnauskas K., Buzaite O., Vogel F., Jandrig B., Razanskas R., Staniulis J., Scherneck S., Krüger D.H., and Ulrich R., Biol Chem 380, 381-386, 1999.Google Scholar
  16. 16.
    Scherneck S., and Feunteun J., in Barbanti-Brodano G., Bendinelli M., and Friedmann H. (eds.) DNA Tumor Viruses-Oncogenic Mechanisms, Plenum Press, New York, pp. 1-14, 1996.Google Scholar
  17. 17.
    Giri I. and Danos O., Trends Genet 2, 227-232, 1986.Google Scholar
  18. 18.
    Dawe C.J., Freund R., Mandel G., Balmer-Hofer K, Talmage D., and Benjamin T.L., Am J Pathol 127, 243-261, 1987.Google Scholar
  19. 19.
    Bender E., Schramm T., Graffi A., and Schneider F., Arch Geschwulstforsch 34, 144-151, 1969.Google Scholar
  20. 20.
    Graffi A., Bender E., Schramm T., Kuhn W., and Schneider F., Proc Natl Acad Sci USA 64, 1172-1175, 1969.Google Scholar
  21. 21.
    De la Roche Saint Andre C., Mazur S., and Feunteun J., J Virol 67, 7172-7180, 1993.Google Scholar
  22. 22.
    Mazur S., Feunteun J., and De la Roche Saint André C., J Virol 69, 3059-3066, 1995.Google Scholar
  23. 23.
    Mazur S., Goodhardt M., Feunteun J., and De la Roche Saint André C., J Virol 68, 5629-5637, 1994.Google Scholar
  24. 24.
    Prokoph H., Jandrig B., Arnold W., and Scherneck S., Arch Virol 142, 53-63, 1997.Google Scholar
  25. 25.
    Prokoph H., Arnold W., Schwartz A., and Scherneck S., J Gen Virol 77, 2165-2172, 1996.Google Scholar
  26. 26.
    Barthold S.W., Bhatt P.N., and Johnson E.A., Anim Sci 37, 283-287, 1987.Google Scholar
  27. 27.
    Hoffman S., Arnold W., Becker K., Rüdiger K.-D., and Scherneck S., Biol Zentralbl. 108, 13-18, 1989.Google Scholar
  28. 28.
    De la Roche Saint Andre C., Harper F., and Feunteun J., Virology 177, 532-540, 1990.Google Scholar
  29. 29.
    Diamandopoulos G.T., Science 176, 173-175, 1972.Google Scholar
  30. 30.
    De la Roche Saint Andre C. and Feunteun J., J Gen Virol 74, 125-128, 1993.Google Scholar
  31. 31.
    Bastien C. and Feunteun J., Oncogene 2, 129-135, 1988.Google Scholar
  32. 32.
    Pipas J.M., J Virol 66, 3979-3985, 1992.Google Scholar
  33. 33.
    Rassoulzadegan M., Cowie A., Carr A., Glaichenhaus N. Kamen R., and Cuzin F., Nature 300, 713-718, 1982.Google Scholar
  34. 34.
    Goutebrouze L. and Feunteun J., J Virol 66, 2495-2504, 1992.Google Scholar
  35. 35.
    Cherington V., Morgan B., Spiegelman B.M., and Roberts T.M., Proc Natl Acad Sci U.S.A. 83, 4307-4311, 1986.Google Scholar
  36. 36.
    Dyson N., Bernards R., Friend S.H., Gooding L.R., Hassell J.A., Major E.O., Pipas J.M., Vandyke T., and Harlow E., J Virol 64, 1353-1356, 1990.Google Scholar
  37. 37.
    Goutebrouze L., De la Roche Saint Andre C., Scherneck S., and Feunteun S., Oncogene 8, 685-693, 1993.Google Scholar
  38. 38.
    Kiefer F., Courtneidge S.A., and Wagner E.F., Adv Cancer Res 64, 125-158, 1994.Google Scholar
  39. 39.
    Goutebrouze L., Dunant N.M., Ballmer-Hofer K., and Feunteun J., J Virol 71, 1436-1442, 1997.Google Scholar
  40. 40.
    Dilworth S.M., Trends Microbiol 3, 31-35, 1995.Google Scholar
  41. 41.
    Dunant N. and Ballmer-Hofer K., Cell Signal 9, 385-393, 1997.Google Scholar
  42. 42.
    Brizuela L., Ulug E.T., Jones M.A., and Courtneidge S.A., Eur J Immunol 25, 385-393, 1995.Google Scholar
  43. 43.
    Courtneidge S.A., Goutebrouze L., Cartwright A., Heber A., Scherneck S., and Feunteun J., J Virol 65, 3301-3308, 1991.Google Scholar
  44. 44.
    Krüger D.H., Ulrich R., and Gerlich W.H., Biol Chem 380, 275-276, 1999.Google Scholar
  45. 45.
    Gedvilaite A., Frömmel C., Sausnauskas K., Micheel B., Özel M., Behrsing O., Staniulis J., Jandrig B., Scherneck S., and Ulrich R., Virology 273, 21-35, 2000.Google Scholar
  46. 46.
    Forstova J., Krauzewicz N., Sandig V., Elliott J., Palkova Z., Strauss M., and Griffin B.E., Hum Gene Ther 6, 297-306, 1995.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Siegfried Scherneck
    • 1
  • Rainer Ulrich
    • 2
  • Jean Feunteun
    • 3
  1. 1.Max Delbrück Center for Molecular MedicineBerlinGermany
  2. 2.Institute of Virology, Charité Medical SchoolHumboldt UniversityBerlinGermany
  3. 3.Laboratoire de Génétique OncologiqueCNRS, Institut Gutave RoussyVillejuifFrance

Personalised recommendations