Abstract
In a 30-week preliminary study and a follow-up 22-week study (2 × 2 factorial), dimethylhydrazine (DMH)injections effectively induced colon tumors in Fischer-344rats. How this incidence of colon tumors might be affected by cellulose (preliminary study) or by calcium and folic acid (follow-up study) was examined. Cellulose in the dietappeared to provide some protection against DMH-induced colon tumors, but the protective effect of calcium was moreevident; normal levels of calcium (500 mg per 100 g diet), but not of folic acid (0.1 mg per 100 g diet), provided protection against colon tumors. The effect due to calciumwas observed whether viewed in terms of total number of tumors (p lt 0.01) or number of tumors per tumor-bearing rat(p < 0.01).
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Ranhotra, G., Gelroth, J., Glaser, B. et al. Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats. Plant Foods Hum Nutr 54, 295–303 (1999). https://doi.org/10.1023/A:1008149107282
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DOI: https://doi.org/10.1023/A:1008149107282