Article PDF
References
Aidoo A, Lyn-Cook LE, Mittelstaedt RA, Heflich RH, Casciano DA. Induction of 6-thioguanine-resistant lymphocytes in Fischer 344 rats follow in vivo exposure to N-ethyl-N-nitrosourea and cyclophosphamide. Environ Mol Mutagen 1991; 17: 141–51.
Albertini RJ, Hayes RB. Somatic mutations in cancer epidemiology. Applications of Biomarkers to Cancer Epidemiology (eds P Toniolo, P Bofetta, D Shuker, N Rothman, B Hulka, N Pearce) IARC Scientific Publication No. 142 1996 (submitted).
Albertini RJ, Nicklas JA, O'Neill JP. Future directions for evaluating human genetic and cancer risk from environmental exposures. Environ Health Perspect 1986; 104 (Suppl 3): 503–10.
Albertini RJ, Robison SH. Human Population Monitoring. In: Genetic Toxicology (eds AP Li, PH Heflich). Boca Raton: CRC Press 1991; 375–420.
Bonassi S, Abbondandolo A, Camurri L, Dal Pra L, De Ferrari M, Degrassi F, Forni A, Lamberti L, Lando C, Padovani P, Sbrana I, Vecchio D, Puntoni R. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet Cytogenet 1995; 79: 133–35.
Branda RF, O'Neill JP, Sullivan LM, Albertini RJ. Factors influencing mutation at the hprt locus in T-lymphocytes: Women treated for breast cancer. Cancer Res 1991; 51: 6603–7.
Cole J, Skopek TR. Intemational Commission for Protection against Environmental Mutagens and Carcinogens, Working Paper 3, Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutation Res 1994; 304: 33–106.
Committee on Biological Markers of the National Research Council Biological Markers in Environmental Health Research, Environmental Health Perspectives 1987; 74: 3–9.
Cosma GN and Garte SJ. Human gene inducibility: A marker of exposure and susceptibility to environmental toxicants. In: Molecular Environmental Biology (ed Garte SJ). Lewis Publishers, Boca Raton 1994; pp 225–46.
Eistman DA and Rupta DS. Fluorescence in situ hybridization. Application to Environmental Mutagenesis (eds DH Phillips, S Venitt). BIOS Scientific Publishers, Ltd., Oxford Press 1995; pp 315–39.
Finette BA, Poseno T, Albertini RJ. V(D)J recombinase mediated HPRT mutations in peripheral blood lymphocytes of normal children. Cancer Res 1996; 56: 1405–12.
Grdina DJ, Carnes BA, Grahn D, Sigdestad CP. Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Res 1991; 51: 4125–30.
Grdina DJ, Ktaoka Y, Basic I, Perrin J. The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyltransferase locus in mouse splenocytes when administered prior to or following irradiation. Carcino-genesis 1992; 13: 811–4.
Grant S, Bigbee WL. In vivo somatic mutation and segregation at the human glycophorin A (GPA) locus. Mutat Res 1993; 288: 163–72.
Hagmar L, Brogger A, Hansteen I-L, Heim S, Hogstedt B, Knudsen L, Lambert B, Linnainmaa K, Mitelman F, Nordenson I, Reuterwall C, Salomaa S, Skerfving S, Sorsa M. Cancer risks in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic study group on the health risk of chromosome damage. Cancer Res 1994; 54: 2919–22.
Harris CC, Vahakangas K, Newman MJ, Trivers GE, Sharnsuddin A, Sinopoli N, Mann DL, Wright WE. Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc Natl Acad Sci USA 1985; 82: 6672–6.
Haugen A, Becker G, Benstad C, Vahakangas K, Trivers GE, Newman MJ, Harris CC. Determination of polycyclic aromatic hydrocarbons in the urine, benzi[a]pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Res 1986; 46: 4178–83.
Harnden DG. Inherited Susceptibility to Mutation. In: Environmental Mutagenesis (eds DH Phillips, S Venitt). BIOS Scientific Publishers, Ltd., Oxford 1995; pp 61–81.
Hulka BS, Margolin BH. Methodological issues in epidemiologic studies using biologic markers. Amer J Epidemiol 1992;135.
Kleinerman RA, Littlefield LG, Tarone RE, Sayer AM, Cookfair DL, Wactawski-Wende J, Inskip PD, Block A, Ramesh KH, Boice JD Jr. Chromosome aberrations in lyrnphocytes from women irradiated for benign and malignant gynecological disease. Radiat Res 1994; 139: 40–6.
Phillips DH, Farmer PB. Protein and DNA adducts as biomarkers of exposure to environmental mutagens. In: Environmental Mutagens (eds DH Phillips, S Venitt). BIOS Scientific Publishers, Ltd., Oxford 1995; pp 367–95.
Rainville IR, Albertini RJ, O'Neill JP, Nicklas JA. Breakpoints and junctional regions of intragenic deletions in the hprt gene in human T-cells. Som Cell Molec Gen 1995; 21(5): 309–26.
Rothman N, Haas R, Hayes RB, Li G-L, Wiemels J, Campleman S, Quintana PJE, Xi L-J, Dosemeci M, Titenko-Holland N, Meyer KB, Lu W, Zhang LP, Bechtold W, Wang Y-Z, Kolachana P, Yin S-N, Blot W, Smith MT. Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans. Proc Nat Acad Sci USA 1995; 92: 4069–73.
Rothman N, Stewart WF, Rabkin CS, Schulte PA. The development, validation, and application of biomarkers for early biologic effects. Biomarkers and Occupational Health: Progress and Perspectives 1995; pp 109–15.
Schatzkin A, Freedman LS, Schiffman MH, Dawsey SM. Validation of intermediate endpoints in cancer research. J Natl Cancer Inst 1990: 82: 1746–52.
Schulte PA. Use of biological markers in occupational health research and practice. J Toxicol and Environ Health 1993; 40: 359–66.
Smith G, Smith CAP, Wolf CR. Pharmacogenetic polymorphisms. In: Environmental Mutagenesis (eds DH Phillips, S Venitt). BIOS Scientific Publishers, Ltd., Oxford 1995: 83–106.
Swiger RR, Tucker JD. Fluorescence in situ hybridization: A brief review. Environ & Molec Mutagenesis 1996; 27: 245–54.
Tice RR. The single cell gel/Comet assay: A microgel electrophoretic technique for the detection of DNA damage and repair in individual cells. In: Environmental Mutagenesis (eds DH Phillips, S Venitt). BIOS Scientific Publishers, Ltd., Oxford 1995; 315–39.
Tucker JP, Eastmond DA, Littlefield LG. Cytogenetic end-points useful as biological dosimeters and predictors of risk in epidemiological studies. IARC Scientific Publication 1996 No. 142.
Turner DR, Grist SA, Janatipour M, Morley AA. Mutations in human lymphocytes commonly involve gene duplication and resemble those seen in cancer cells. Proc Nat Acad Sci USA 1988 85: 3189–93.
Van Houten B, Albertini RJ. DNA damage and repair. In: Pathology of Environmental and Occupational Disease (ed Craighead JE)., Mosby 1995; pp 311–27.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Albertini, R.J. The use and interpretation of biomarkers of environmental genotoxicity in humans. Biotherapy 11, 155–167 (1998). https://doi.org/10.1023/A:1007990300835
Issue Date:
DOI: https://doi.org/10.1023/A:1007990300835